Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation

Variants of the oncogenic EML4-ALK fusion protein contain a similar region of ALK encompassing the kinase domain, but different portions of EML4. Here, we show that EML4-ALK V1 and V3 proteins form cytoplasmic foci that contain components of the MAPK, PLCγ and PI3K signalling pathways. The ALK inhib...

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Veröffentlicht in:	EMBO reports 2021-12, Vol.22 (12), p.e53693-n/a
Hauptverfasser:	Sampson, Josephina, Richards, Mark W, Choi, Jene, Fry, Andrew M, Bayliss, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Anaplastic Lymphoma Kinase - genetics cancer Carcinoma, Non-Small-Cell Lung Domains EMBO03 EMBO37 EMBO40 Fusion protein Humans Inhibitors Kinases Lung cancer Lung Neoplasms - genetics MAP kinase Microtubules Mutants Mutation Non-small cell lung carcinoma NSCLC Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism phase separation Protein Conformation Protein Kinase Inhibitors - pharmacology Protein structure Proteins Signal transduction Signaling signalling Trimers tyrosine kinase inhibitors
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