Curcumin analog GO‐Y030 boosts the efficacy of anti‐PD‐1 cancer immunotherapy

Regulatory T cells (Tregs) in the tumor microenvironment regulate tumor immunity. Programmed cell death protein 1 (PD‐1) is known to be expressed on Tregs and plays crucial roles in suppressing tumor immunity. However, the immune checkpoint inhibitor, anti‐PD‐1 antibody, is known to promote the prol...

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Veröffentlicht in:	Cancer science 2021-12, Vol.112 (12), p.4844-4852
Hauptverfasser:	MaruYama, Takashi, Kobayashi, Shuhei, Shibata, Hiroyuki, Chen, WanJun, Owada, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Animals Antibodies Apoptosis Benzene Derivatives - administration & dosage Benzene Derivatives - pharmacology Cancer Cancer immunotherapy CD4 antigen Cell death Cell growth Cells, Cultured Curcumin Drug Synergism Flow cytometry Gene expression GO‐Y030 Helper cells Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - administration & dosage Immune Checkpoint Inhibitors - pharmacology Immunoregulation Immunotherapy Ketones - administration & dosage Ketones - pharmacology Laboratories Lactic acid Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - metabolism Melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - genetics Melanoma, Experimental - metabolism Metabolism Mice Original PD-1 protein programmed cell death protein 1 Proteins regulatory T cells Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Treatment Outcome Tumor microenvironment Tumor Microenvironment - drug effects Tumor-infiltrating lymphocytes Tumors Xenograft Model Antitumor Assays
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