The human telomeric proteome during telomere replication

Abstract Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication mach...

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Veröffentlicht in:	Nucleic acids research 2021-12, Vol.49 (21), p.12119-12135
Hauptverfasser:	Lin, Chih-Yi Gabriela, Näger, Anna Christina, Lunardi, Thomas, Vančevska, Aleksandra, Lossaint, Gérald, Lingner, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Replication Gene regulation, Chromatin and Epigenetics HEK293 Cells HeLa Cells Histones - metabolism Humans Shelterin Complex - metabolism Telomerase - metabolism Telomere - metabolism Telomere Shortening Telomere-Binding Proteins - metabolism
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