Broken symmetry between RNA enantiomers in a crystal lattice
Abstract Explaining the origin of the homochirality of biological molecules requires a mechanism of disrupting the natural equilibrium between enantiomers and amplifying the initial imbalance to significant levels. Authors of existing models have sought an explanation in the parity-breaking weak nuc...
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| Veröffentlicht in: | Nucleic acids research 2021-12, Vol.49 (21), p.12535-12539 |
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| container_issue | 21 |
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| container_title | Nucleic acids research |
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| creator | Kiliszek, Agnieszka Błaszczyk, Leszek Bejger, Magdalena Rypniewski, Wojciech |
| description | Abstract
Explaining the origin of the homochirality of biological molecules requires a mechanism of disrupting the natural equilibrium between enantiomers and amplifying the initial imbalance to significant levels. Authors of existing models have sought an explanation in the parity-breaking weak nuclear force, in some selectively acting external factor, or in random fluctuations that subsequently became amplified by an autocatalytic process. We have obtained crystals in which l- and d-enantiomers of short RNA duplexes assemble in an asymmetric manner. These enantiomers make different lattice contacts and have different exposures to water and metal ions present in the crystal. Apparently, asymmetry between enantiomers can arise upon their mutual interactions and then propagate via crystallization. Asymmetric racemic compounds are worth considering as possible factors in symmetry breaking and enantioenrichment that took place in the early biosphere. |
| doi_str_mv | 10.1093/nar/gkab480 |
| format | Article |
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Explaining the origin of the homochirality of biological molecules requires a mechanism of disrupting the natural equilibrium between enantiomers and amplifying the initial imbalance to significant levels. Authors of existing models have sought an explanation in the parity-breaking weak nuclear force, in some selectively acting external factor, or in random fluctuations that subsequently became amplified by an autocatalytic process. We have obtained crystals in which l- and d-enantiomers of short RNA duplexes assemble in an asymmetric manner. These enantiomers make different lattice contacts and have different exposures to water and metal ions present in the crystal. Apparently, asymmetry between enantiomers can arise upon their mutual interactions and then propagate via crystallization. Asymmetric racemic compounds are worth considering as possible factors in symmetry breaking and enantioenrichment that took place in the early biosphere.</description><identifier>ISSN: 0305-1048</identifier><identifier>ISSN: 1362-4962</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/gkab480</identifier><identifier>PMID: 34107036</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Base Sequence ; Crystallization ; Crystallography, X-Ray ; Models, Molecular ; Nucleic Acid Conformation ; RNA - chemistry ; RNA - genetics ; RNA, Bacterial - chemistry ; RNA, Bacterial - genetics ; RNA, Ribosomal, 5S - chemistry ; RNA, Ribosomal, 5S - genetics ; Stereoisomerism ; Structural Biology ; Thermus - genetics</subject><ispartof>Nucleic acids research, 2021-12, Vol.49 (21), p.12535-12539</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-22a65be7f6444b15d3b8f447e812f03f9d86c71b92abdf30c4c95ae45a8ea1703</citedby><cites>FETCH-LOGICAL-c412t-22a65be7f6444b15d3b8f447e812f03f9d86c71b92abdf30c4c95ae45a8ea1703</cites><orcidid>0000-0002-6097-5518 ; 0000-0002-1907-4857 ; 0000-0003-1660-9745 ; 0000-0002-2871-7535</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643679/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34107036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiliszek, Agnieszka</creatorcontrib><creatorcontrib>Błaszczyk, Leszek</creatorcontrib><creatorcontrib>Bejger, Magdalena</creatorcontrib><creatorcontrib>Rypniewski, Wojciech</creatorcontrib><title>Broken symmetry between RNA enantiomers in a crystal lattice</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>Abstract
Explaining the origin of the homochirality of biological molecules requires a mechanism of disrupting the natural equilibrium between enantiomers and amplifying the initial imbalance to significant levels. Authors of existing models have sought an explanation in the parity-breaking weak nuclear force, in some selectively acting external factor, or in random fluctuations that subsequently became amplified by an autocatalytic process. We have obtained crystals in which l- and d-enantiomers of short RNA duplexes assemble in an asymmetric manner. These enantiomers make different lattice contacts and have different exposures to water and metal ions present in the crystal. Apparently, asymmetry between enantiomers can arise upon their mutual interactions and then propagate via crystallization. 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Explaining the origin of the homochirality of biological molecules requires a mechanism of disrupting the natural equilibrium between enantiomers and amplifying the initial imbalance to significant levels. Authors of existing models have sought an explanation in the parity-breaking weak nuclear force, in some selectively acting external factor, or in random fluctuations that subsequently became amplified by an autocatalytic process. We have obtained crystals in which l- and d-enantiomers of short RNA duplexes assemble in an asymmetric manner. These enantiomers make different lattice contacts and have different exposures to water and metal ions present in the crystal. Apparently, asymmetry between enantiomers can arise upon their mutual interactions and then propagate via crystallization. Asymmetric racemic compounds are worth considering as possible factors in symmetry breaking and enantioenrichment that took place in the early biosphere.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>34107036</pmid><doi>10.1093/nar/gkab480</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6097-5518</orcidid><orcidid>https://orcid.org/0000-0002-1907-4857</orcidid><orcidid>https://orcid.org/0000-0003-1660-9745</orcidid><orcidid>https://orcid.org/0000-0002-2871-7535</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Base Sequence Crystallization Crystallography, X-Ray Models, Molecular Nucleic Acid Conformation RNA - chemistry RNA - genetics RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Ribosomal, 5S - chemistry RNA, Ribosomal, 5S - genetics Stereoisomerism Structural Biology Thermus - genetics |
| title | Broken symmetry between RNA enantiomers in a crystal lattice |
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