Effects of Active Vitamin D or FGF23 Antibody on Hyp Mice Dentoalveolar Tissues

Mutations in the PHEX gene lead to X-linked hypophosphatemia (XLH), a form of inherited rickets featuring elevated fibroblast growth factor 23 (FGF23), reduced 1,25-dihydroxyvitamin D (1,25D), and hypophosphatemia. Hyp mutant mice replicate the XLH phenotype, including dentin, alveolar bone, and cem...

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Veröffentlicht in:	Journal of dental research 2021-12, Vol.100 (13), p.1482-1491
Hauptverfasser:	Lira dos Santos, E.J., Chavez, M.B., Tan, M.H., Mohamed, F.F., Kolli, T.N., Foster, B.L., Liu, E.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar bone Animals Antibodies Blocking antibodies Bone mineral density Bone sialoprotein Cementum Computed tomography Dentin Familial Hypophosphatemic Rickets - drug therapy Fibroblast Growth Factor-23 Fibroblast Growth Factors Hypophosphatemia Immunohistochemistry Male Mandible Mice Mineralization Normocalcemia Osteocytes Osteopontin Periodontal ligament Phenotypes Research Reports Rickets Vitamin D X-Ray Microtomography
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