Characterization of mutant type VII collagens underlying the inversa subtype of recessive dystrophic epidermolysis bullosa

•Patients with RDEB lack functional Type VII collagen (C7).•The Inversa subtype (RDEB-I) affects body areas of higher temperature.•The structural and functional abnormalities of RDEB-I C7 are temperature-dependent.•The abnormal RDEB-I fibroblast phenotype is correctable at lower temperatures. Patien...

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