Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study
Helicobacter pylori infection and serum pepsinogen values are strongly related with stomach cancer. The aim of this study was to know what were these factors among general population. Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most...
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| Veröffentlicht in: | Journal of epidemiology 2005, Vol.15 Suppl 2 (Supplement_II), p.S126-S133 |
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| container_issue | Supplement_II |
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| container_title | Journal of epidemiology |
| container_volume | 15 Suppl 2 |
| creator | Kikuchi, Shogo Yagyu, Kiyoko Obata, Yuki Yingsong, Lin Yatsuya, Hiroshi Hoshiyama, Yoshiharu Kondo, Takaaki Sakata, Kiyoshi Mizoue, Tetsuya Tokui, Noritaka Fujino, Yoshihisa Tamakoshi, Akiko Toyoshima, Hideaki Ishibashi, Teruo Hayakawa, Norihiko Yoshimura, Takesumi |
| description | Helicobacter pylori infection and serum pepsinogen values are strongly related with stomach cancer. The aim of this study was to know what were these factors among general population.
Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most of them were from rural areas of Japan. Using frozen sera, pepsinogen I (PG I) and II (PG II) values and H. pylori antibody were measured. Those with PG I less than 50 ng/mL and the ratio of PG I to PG II (PG I/II) was less than 2.0 were defined as severe, those with PG I less than 70 ng/ml and PG I/II less than 3.0 were defined as mild and the other subjects were defined as no serological atrophy.
About 70% of the subjects were H. pylori seropositive and the seroprevalence did not depend on age or sex. Percentages of those with severe serological atrophy increased with age from 10% in those aged 40-49 years to 38% in 70 and more, and percentages of those with mild serological atrophy were about 30% independent of age.
The subjects, who were expected to represent populations of rural area of Japan, had high prevalence of both H. pylori infection and serological atrophy of gastric mucosa. These facts should be considered in discussing results of the nested case-control study. |
| doi_str_mv | 10.2188/jea.15.S126 |
| format | Article |
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Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most of them were from rural areas of Japan. Using frozen sera, pepsinogen I (PG I) and II (PG II) values and H. pylori antibody were measured. Those with PG I less than 50 ng/mL and the ratio of PG I to PG II (PG I/II) was less than 2.0 were defined as severe, those with PG I less than 70 ng/ml and PG I/II less than 3.0 were defined as mild and the other subjects were defined as no serological atrophy.
About 70% of the subjects were H. pylori seropositive and the seroprevalence did not depend on age or sex. Percentages of those with severe serological atrophy increased with age from 10% in those aged 40-49 years to 38% in 70 and more, and percentages of those with mild serological atrophy were about 30% independent of age.
The subjects, who were expected to represent populations of rural area of Japan, had high prevalence of both H. pylori infection and serological atrophy of gastric mucosa. These facts should be considered in discussing results of the nested case-control study.</description><identifier>ISSN: 0917-5040</identifier><identifier>EISSN: 1349-9092</identifier><identifier>DOI: 10.2188/jea.15.S126</identifier><identifier>PMID: 16127224</identifier><language>eng</language><publisher>Japan: Japan Epidemiological Association</publisher><subject>Adult ; Aged ; Antibodies, Bacterial - blood ; Biomarkers - blood ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Gastric Mucosa - pathology ; Health Status ; Helicobacter Infections - blood ; Helicobacter Infections - epidemiology ; Helicobacter pylori - immunology ; Humans ; Japan ; Male ; Middle Aged ; Original ; Pepsinogen A - blood ; Prevalence ; Risk Factors ; Rural Population ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - microbiology</subject><ispartof>Journal of epidemiology, 2005, Vol.15 Suppl 2 (Supplement_II), p.S126-S133</ispartof><rights>2005 Japan Epidemiological Association. 2005 Japan Epidemiological Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-75dc7c8024213b3b038d22943f09f6f29b8801a6bacd78e42b86b5e584803e863</citedby><cites>FETCH-LOGICAL-c546t-75dc7c8024213b3b038d22943f09f6f29b8801a6bacd78e42b86b5e584803e863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639043/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639043/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16127224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kikuchi, Shogo</creatorcontrib><creatorcontrib>Yagyu, Kiyoko</creatorcontrib><creatorcontrib>Obata, Yuki</creatorcontrib><creatorcontrib>Yingsong, Lin</creatorcontrib><creatorcontrib>Yatsuya, Hiroshi</creatorcontrib><creatorcontrib>Hoshiyama, Yoshiharu</creatorcontrib><creatorcontrib>Kondo, Takaaki</creatorcontrib><creatorcontrib>Sakata, Kiyoshi</creatorcontrib><creatorcontrib>Mizoue, Tetsuya</creatorcontrib><creatorcontrib>Tokui, Noritaka</creatorcontrib><creatorcontrib>Fujino, Yoshihisa</creatorcontrib><creatorcontrib>Tamakoshi, Akiko</creatorcontrib><creatorcontrib>Toyoshima, Hideaki</creatorcontrib><creatorcontrib>Ishibashi, Teruo</creatorcontrib><creatorcontrib>Hayakawa, Norihiko</creatorcontrib><creatorcontrib>Yoshimura, Takesumi</creatorcontrib><creatorcontrib>JACC Study Group</creatorcontrib><title>Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study</title><title>Journal of epidemiology</title><addtitle>J Epidemiol</addtitle><description>Helicobacter pylori infection and serum pepsinogen values are strongly related with stomach cancer. The aim of this study was to know what were these factors among general population.
Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most of them were from rural areas of Japan. Using frozen sera, pepsinogen I (PG I) and II (PG II) values and H. pylori antibody were measured. Those with PG I less than 50 ng/mL and the ratio of PG I to PG II (PG I/II) was less than 2.0 were defined as severe, those with PG I less than 70 ng/ml and PG I/II less than 3.0 were defined as mild and the other subjects were defined as no serological atrophy.
About 70% of the subjects were H. pylori seropositive and the seroprevalence did not depend on age or sex. Percentages of those with severe serological atrophy increased with age from 10% in those aged 40-49 years to 38% in 70 and more, and percentages of those with mild serological atrophy were about 30% independent of age.
The subjects, who were expected to represent populations of rural area of Japan, had high prevalence of both H. pylori infection and serological atrophy of gastric mucosa. These facts should be considered in discussing results of the nested case-control study.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Bacterial - blood</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gastric Mucosa - pathology</subject><subject>Health Status</subject><subject>Helicobacter Infections - blood</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter pylori - immunology</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Pepsinogen A - blood</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Rural Population</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - microbiology</subject><issn>0917-5040</issn><issn>1349-9092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1r3DAQxUVpaDZpT70HnXop3ujLsnwphCVNGhZy2PQsZHm88WJLriQv7KV_exR2SdrTwMxv3jzmIfSVkiWjSl3vwCxpudxQJj-gBeWiLmpSs49oQWpaFSUR5BxdxLgjhEvFyCd0TiVlFWNigf5uIMwjnmCKvfNbcHhvhhkiNq7F9zD01jfGJgh4Ogw-9Dgmk-Y8Hr3bYutdCn7AcW52YFPEvsMGO4gJWmxNhOKNSHN7wL3D6Rnww81qdex8RmedGSJ8OdVL9Pvn7dPqvlg_3v1a3awLWwqZiqpsbWUVYYJR3vCGcNUyVgvekbqTHasbpQg1MlttKwWCNUo2JZRKKMJBSX6Jfhx1p7kZobWQXZlBT6EfTThob3r9_8T1z3rr9zrv1kTwLPDtJBD8n_yfpMc-WhgG48DPUUtVsopKksHvR9AGH2OA7u0IJfo1L53z0rTUr3ll-upfX-_sKSD-Au6qk9Q</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Kikuchi, Shogo</creator><creator>Yagyu, Kiyoko</creator><creator>Obata, Yuki</creator><creator>Yingsong, Lin</creator><creator>Yatsuya, Hiroshi</creator><creator>Hoshiyama, Yoshiharu</creator><creator>Kondo, Takaaki</creator><creator>Sakata, Kiyoshi</creator><creator>Mizoue, Tetsuya</creator><creator>Tokui, Noritaka</creator><creator>Fujino, Yoshihisa</creator><creator>Tamakoshi, Akiko</creator><creator>Toyoshima, Hideaki</creator><creator>Ishibashi, Teruo</creator><creator>Hayakawa, Norihiko</creator><creator>Yoshimura, Takesumi</creator><general>Japan Epidemiological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2005</creationdate><title>Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study</title><author>Kikuchi, Shogo ; Yagyu, Kiyoko ; Obata, Yuki ; Yingsong, Lin ; Yatsuya, Hiroshi ; Hoshiyama, Yoshiharu ; Kondo, Takaaki ; Sakata, Kiyoshi ; Mizoue, Tetsuya ; Tokui, Noritaka ; Fujino, Yoshihisa ; Tamakoshi, Akiko ; Toyoshima, Hideaki ; Ishibashi, Teruo ; Hayakawa, Norihiko ; Yoshimura, Takesumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-75dc7c8024213b3b038d22943f09f6f29b8801a6bacd78e42b86b5e584803e863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Bacterial - blood</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gastric Mucosa - pathology</topic><topic>Health Status</topic><topic>Helicobacter Infections - blood</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter pylori - immunology</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Pepsinogen A - blood</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Rural Population</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach Neoplasms - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikuchi, Shogo</creatorcontrib><creatorcontrib>Yagyu, Kiyoko</creatorcontrib><creatorcontrib>Obata, Yuki</creatorcontrib><creatorcontrib>Yingsong, Lin</creatorcontrib><creatorcontrib>Yatsuya, Hiroshi</creatorcontrib><creatorcontrib>Hoshiyama, Yoshiharu</creatorcontrib><creatorcontrib>Kondo, Takaaki</creatorcontrib><creatorcontrib>Sakata, Kiyoshi</creatorcontrib><creatorcontrib>Mizoue, Tetsuya</creatorcontrib><creatorcontrib>Tokui, Noritaka</creatorcontrib><creatorcontrib>Fujino, Yoshihisa</creatorcontrib><creatorcontrib>Tamakoshi, Akiko</creatorcontrib><creatorcontrib>Toyoshima, Hideaki</creatorcontrib><creatorcontrib>Ishibashi, Teruo</creatorcontrib><creatorcontrib>Hayakawa, Norihiko</creatorcontrib><creatorcontrib>Yoshimura, Takesumi</creatorcontrib><creatorcontrib>JACC Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kikuchi, Shogo</au><au>Yagyu, Kiyoko</au><au>Obata, Yuki</au><au>Yingsong, Lin</au><au>Yatsuya, Hiroshi</au><au>Hoshiyama, Yoshiharu</au><au>Kondo, Takaaki</au><au>Sakata, Kiyoshi</au><au>Mizoue, Tetsuya</au><au>Tokui, Noritaka</au><au>Fujino, Yoshihisa</au><au>Tamakoshi, Akiko</au><au>Toyoshima, Hideaki</au><au>Ishibashi, Teruo</au><au>Hayakawa, Norihiko</au><au>Yoshimura, Takesumi</au><aucorp>JACC Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study</atitle><jtitle>Journal of epidemiology</jtitle><addtitle>J Epidemiol</addtitle><date>2005</date><risdate>2005</risdate><volume>15 Suppl 2</volume><issue>Supplement_II</issue><spage>S126</spage><epage>S133</epage><pages>S126-S133</pages><issn>0917-5040</issn><eissn>1349-9092</eissn><abstract>Helicobacter pylori infection and serum pepsinogen values are strongly related with stomach cancer. The aim of this study was to know what were these factors among general population.
Subjects were randomly selected 633 control subjects in a nested case-control study for risk of stomach cancer. Most of them were from rural areas of Japan. Using frozen sera, pepsinogen I (PG I) and II (PG II) values and H. pylori antibody were measured. Those with PG I less than 50 ng/mL and the ratio of PG I to PG II (PG I/II) was less than 2.0 were defined as severe, those with PG I less than 70 ng/ml and PG I/II less than 3.0 were defined as mild and the other subjects were defined as no serological atrophy.
About 70% of the subjects were H. pylori seropositive and the seroprevalence did not depend on age or sex. Percentages of those with severe serological atrophy increased with age from 10% in those aged 40-49 years to 38% in 70 and more, and percentages of those with mild serological atrophy were about 30% independent of age.
The subjects, who were expected to represent populations of rural area of Japan, had high prevalence of both H. pylori infection and serological atrophy of gastric mucosa. These facts should be considered in discussing results of the nested case-control study.</abstract><cop>Japan</cop><pub>Japan Epidemiological Association</pub><pmid>16127224</pmid><doi>10.2188/jea.15.S126</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of epidemiology, 2005, Vol.15 Suppl 2 (Supplement_II), p.S126-S133 |
| issn | 0917-5040 1349-9092 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Aged Antibodies, Bacterial - blood Biomarkers - blood Case-Control Studies Cross-Sectional Studies Female Gastric Mucosa - pathology Health Status Helicobacter Infections - blood Helicobacter Infections - epidemiology Helicobacter pylori - immunology Humans Japan Male Middle Aged Original Pepsinogen A - blood Prevalence Risk Factors Rural Population Stomach Neoplasms - epidemiology Stomach Neoplasms - microbiology |
| title | Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study |
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