Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring

Human epidemiological studies implicate exposure to infection during gestation in the etiology of neurodevelopmental disorders. Animal models of maternal immune activation (MIA) have identified the maternal immune response as the critical link between maternal infection and aberrant offspring brain...

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Veröffentlicht in:	The Journal of neuroscience 2021-12, Vol.41 (48), p.9971-9987
Hauptverfasser:	Vlasova, Roza M, Iosif, Ana-Maria, Ryan, Amy M, Funk, Lucy H, Murai, Takeshi, Chen, Shuai, Lesh, Tyler A, Rowland, Douglas J, Bennett, Jeffrey, Hogrefe, Casey E, Maddock, Richard J, Gandal, Michael J, Geschwind, Daniel H, Schumann, Cynthia M, Van de Water, Judy, McAllister, A Kimberley, Carter, Cameron S, Styner, Martin A, Amaral, David G, Bauman, Melissa D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animal models Animals Brain Brain - pathology Cognitive ability Cognitive development Cytokines Disease Models, Animal Epidemiology Etiology Female Immune response Immune system Infections Inflammation Interferon Inducers - toxicity Macaca mulatta Magnetic resonance imaging Male Neurodevelopment Neurodevelopmental disorders Neurodevelopmental Disorders - etiology Neurodevelopmental Disorders - pathology Neurogenesis - physiology Offspring Poly I-C - toxicity Pregnancy Pregnancy Complications, Infectious - chemically induced Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - pathology Primates Sickness behavior Substantia alba Substantia grisea
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