Effect of Lithothamnium sp and calcium supplements in strain- and infection-induced bone resorption
To investigate the effect of Lithothamnium sp (LTT) supplement, a calcium-rich alga widely used for mineral reposition, on strain-induced (orthodontic tooth movement [OTM]) and infection-induced bone resorption (periodontal disease [PD]) in mice. Mice were divided into two bone resorption models: on...
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| Veröffentlicht in: | The Angle orthodontist 2014-11, Vol.84 (6), p.980-988 |
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| creator | de Albuquerque Taddei, Silvana Rodrigues Madeira, Mila Fernandes Moreira de Abreu Lima, Izabella Lucas Queiroz-Junior, Celso Martins Moura, Adriana Pedrosa Oliveira, Dauro Douglas Andrade, Jr, Ildeu da Glória Souza, Danielle Teixeira, Mauro Martins da Silva, Tarcília Aparecida |
| description | To investigate the effect of Lithothamnium sp (LTT) supplement, a calcium-rich alga widely used for mineral reposition, on strain-induced (orthodontic tooth movement [OTM]) and infection-induced bone resorption (periodontal disease [PD]) in mice.
Mice were divided into two bone resorption models: one with an orthodontic appliance and the other with PD induced by the oral inoculation of Aggregatibacter actinomycetencomitans (Aa). Both groups were fed a regular diet (vehicle), LTT-rich diet (LTT), or calcium-rich diet (CaCO3). Alveolar bone resorption (ABR), the number of osteoclasts, and the levels of tumor necrosis factor α (TNF-α), calcium, and vitamin D3 were evaluated.
The number of osteoclasts was reduced in LTT and CaCO3 mice, which led to diminished OTM and infection-induced alveolar bone loss. In addition, LTT- and calcium-treated groups also presented decreased levels of TNF-α in periodontal tissues and increased levels of calcium in serum.
These results indicate that the LTT supplement influences ABR, probably due to its calcium content, by affecting osteoclast function and local inflammatory response, thus modulating OTM and PD. |
| doi_str_mv | 10.2319/080313-579.1 |
| format | Article |
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Mice were divided into two bone resorption models: one with an orthodontic appliance and the other with PD induced by the oral inoculation of Aggregatibacter actinomycetencomitans (Aa). Both groups were fed a regular diet (vehicle), LTT-rich diet (LTT), or calcium-rich diet (CaCO3). Alveolar bone resorption (ABR), the number of osteoclasts, and the levels of tumor necrosis factor α (TNF-α), calcium, and vitamin D3 were evaluated.
The number of osteoclasts was reduced in LTT and CaCO3 mice, which led to diminished OTM and infection-induced alveolar bone loss. In addition, LTT- and calcium-treated groups also presented decreased levels of TNF-α in periodontal tissues and increased levels of calcium in serum.
These results indicate that the LTT supplement influences ABR, probably due to its calcium content, by affecting osteoclast function and local inflammatory response, thus modulating OTM and PD.</description><identifier>ISSN: 0003-3219</identifier><identifier>EISSN: 1945-7103</identifier><identifier>DOI: 10.2319/080313-579.1</identifier><identifier>PMID: 24731063</identifier><language>eng</language><publisher>United States: Edward H Angle Education and Research Foundation, Inc</publisher><subject>Acid Phosphatase - analysis ; Aggregatibacter actinomycetemcomitans - physiology ; Alveolar Bone Loss - blood ; Alveolar Bone Loss - microbiology ; Alveolar Bone Loss - prevention & control ; Alveolar Process - drug effects ; Animals ; Bone Density Conservation Agents - therapeutic use ; Calcitriol - blood ; Calcium - blood ; Calcium Carbonate - therapeutic use ; Calcium, Dietary - therapeutic use ; Cell Count ; Dietary Supplements ; Disease Models, Animal ; Isoenzymes - analysis ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Original ; Osteoclasts - drug effects ; Osteoclasts - pathology ; Pasteurellaceae Infections - microbiology ; Periodontal Diseases - microbiology ; Rhodophyta - chemistry ; Tartrate-Resistant Acid Phosphatase ; Tooth Movement Techniques - adverse effects ; Tooth Movement Techniques - instrumentation ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>The Angle orthodontist, 2014-11, Vol.84 (6), p.980-988</ispartof><rights>2014 by The EH Angle Education and Research Foundation, Inc. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-2f4c1eca73b8f82c74fe1d8031181f79255477b384b658b51585e67520c8cc093</citedby><cites>FETCH-LOGICAL-c346t-2f4c1eca73b8f82c74fe1d8031181f79255477b384b658b51585e67520c8cc093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638495/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638495/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24731063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Albuquerque Taddei, Silvana Rodrigues</creatorcontrib><creatorcontrib>Madeira, Mila Fernandes Moreira</creatorcontrib><creatorcontrib>de Abreu Lima, Izabella Lucas</creatorcontrib><creatorcontrib>Queiroz-Junior, Celso Martins</creatorcontrib><creatorcontrib>Moura, Adriana Pedrosa</creatorcontrib><creatorcontrib>Oliveira, Dauro Douglas</creatorcontrib><creatorcontrib>Andrade, Jr, Ildeu</creatorcontrib><creatorcontrib>da Glória Souza, Danielle</creatorcontrib><creatorcontrib>Teixeira, Mauro Martins</creatorcontrib><creatorcontrib>da Silva, Tarcília Aparecida</creatorcontrib><title>Effect of Lithothamnium sp and calcium supplements in strain- and infection-induced bone resorption</title><title>The Angle orthodontist</title><addtitle>Angle Orthod</addtitle><description>To investigate the effect of Lithothamnium sp (LTT) supplement, a calcium-rich alga widely used for mineral reposition, on strain-induced (orthodontic tooth movement [OTM]) and infection-induced bone resorption (periodontal disease [PD]) in mice.
Mice were divided into two bone resorption models: one with an orthodontic appliance and the other with PD induced by the oral inoculation of Aggregatibacter actinomycetencomitans (Aa). Both groups were fed a regular diet (vehicle), LTT-rich diet (LTT), or calcium-rich diet (CaCO3). Alveolar bone resorption (ABR), the number of osteoclasts, and the levels of tumor necrosis factor α (TNF-α), calcium, and vitamin D3 were evaluated.
The number of osteoclasts was reduced in LTT and CaCO3 mice, which led to diminished OTM and infection-induced alveolar bone loss. In addition, LTT- and calcium-treated groups also presented decreased levels of TNF-α in periodontal tissues and increased levels of calcium in serum.
These results indicate that the LTT supplement influences ABR, probably due to its calcium content, by affecting osteoclast function and local inflammatory response, thus modulating OTM and PD.</description><subject>Acid Phosphatase - analysis</subject><subject>Aggregatibacter actinomycetemcomitans - physiology</subject><subject>Alveolar Bone Loss - blood</subject><subject>Alveolar Bone Loss - microbiology</subject><subject>Alveolar Bone Loss - prevention & control</subject><subject>Alveolar Process - drug effects</subject><subject>Animals</subject><subject>Bone Density Conservation Agents - therapeutic use</subject><subject>Calcitriol - blood</subject><subject>Calcium - blood</subject><subject>Calcium Carbonate - therapeutic use</subject><subject>Calcium, Dietary - therapeutic use</subject><subject>Cell Count</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>Isoenzymes - analysis</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Original</subject><subject>Osteoclasts - drug effects</subject><subject>Osteoclasts - pathology</subject><subject>Pasteurellaceae Infections - microbiology</subject><subject>Periodontal Diseases - microbiology</subject><subject>Rhodophyta - chemistry</subject><subject>Tartrate-Resistant Acid Phosphatase</subject><subject>Tooth Movement Techniques - adverse effects</subject><subject>Tooth Movement Techniques - instrumentation</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0003-3219</issn><issn>1945-7103</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkcFu3CAURVHVqJlMusu6YtlFnPDAGNhUqqIkrTRSNskaYQwdIhtcsCv172PPJFG7QsDReffpInQB5IoyUNdEEgas4kJdwQe0AVXzSgBhH9GGEMIqRkGdorNSngmhnNf0EzqltWBAGrZB9tZ7ZyecPN6FaZ-mvRlimAdcRmxih63p7eE6j2PvBhengkPEZcomxOqAhLgaQopViN1sXYfbFB3OrqQ8ru_n6MSbvrjPr-cWPd3dPt78qHYP9z9vvu8qy-pmqqivLThrBGull9SK2jvo1u1AghdqDS9Ey2TdNly2HLjkrhGcEiutJYpt0bejd5zbwXV2CZtNr8ccBpP_6mSC_v8nhr3-lf5o2SxSxRfB11dBTr9nVyY9hGJd35vo0lw0NCAlbZSiC3p5RG1OpWTn38cA0Wsv-tiLXnrRsOBf_o32Dr8VwV4ASRuJXA</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>de Albuquerque Taddei, Silvana Rodrigues</creator><creator>Madeira, Mila Fernandes Moreira</creator><creator>de Abreu Lima, Izabella Lucas</creator><creator>Queiroz-Junior, Celso Martins</creator><creator>Moura, Adriana Pedrosa</creator><creator>Oliveira, Dauro Douglas</creator><creator>Andrade, Jr, Ildeu</creator><creator>da Glória Souza, Danielle</creator><creator>Teixeira, Mauro Martins</creator><creator>da Silva, Tarcília Aparecida</creator><general>Edward H Angle Education and Research Foundation, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141101</creationdate><title>Effect of Lithothamnium sp and calcium supplements in strain- and infection-induced bone resorption</title><author>de Albuquerque Taddei, Silvana Rodrigues ; Madeira, Mila Fernandes Moreira ; de Abreu Lima, Izabella Lucas ; Queiroz-Junior, Celso Martins ; Moura, Adriana Pedrosa ; Oliveira, Dauro Douglas ; Andrade, Jr, Ildeu ; da Glória Souza, Danielle ; Teixeira, Mauro Martins ; da Silva, Tarcília Aparecida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-2f4c1eca73b8f82c74fe1d8031181f79255477b384b658b51585e67520c8cc093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acid Phosphatase - analysis</topic><topic>Aggregatibacter actinomycetemcomitans - physiology</topic><topic>Alveolar Bone Loss - blood</topic><topic>Alveolar Bone Loss - microbiology</topic><topic>Alveolar Bone Loss - prevention & control</topic><topic>Alveolar Process - drug effects</topic><topic>Animals</topic><topic>Bone Density Conservation Agents - therapeutic use</topic><topic>Calcitriol - blood</topic><topic>Calcium - blood</topic><topic>Calcium Carbonate - therapeutic use</topic><topic>Calcium, Dietary - therapeutic use</topic><topic>Cell Count</topic><topic>Dietary Supplements</topic><topic>Disease Models, Animal</topic><topic>Isoenzymes - analysis</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Original</topic><topic>Osteoclasts - drug effects</topic><topic>Osteoclasts - pathology</topic><topic>Pasteurellaceae Infections - microbiology</topic><topic>Periodontal Diseases - microbiology</topic><topic>Rhodophyta - chemistry</topic><topic>Tartrate-Resistant Acid Phosphatase</topic><topic>Tooth Movement Techniques - adverse effects</topic><topic>Tooth Movement Techniques - instrumentation</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Albuquerque Taddei, Silvana Rodrigues</creatorcontrib><creatorcontrib>Madeira, Mila Fernandes Moreira</creatorcontrib><creatorcontrib>de Abreu Lima, Izabella Lucas</creatorcontrib><creatorcontrib>Queiroz-Junior, Celso Martins</creatorcontrib><creatorcontrib>Moura, Adriana Pedrosa</creatorcontrib><creatorcontrib>Oliveira, Dauro Douglas</creatorcontrib><creatorcontrib>Andrade, Jr, Ildeu</creatorcontrib><creatorcontrib>da Glória Souza, Danielle</creatorcontrib><creatorcontrib>Teixeira, Mauro Martins</creatorcontrib><creatorcontrib>da Silva, Tarcília Aparecida</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Angle orthodontist</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Albuquerque Taddei, Silvana Rodrigues</au><au>Madeira, Mila Fernandes Moreira</au><au>de Abreu Lima, Izabella Lucas</au><au>Queiroz-Junior, Celso Martins</au><au>Moura, Adriana Pedrosa</au><au>Oliveira, Dauro Douglas</au><au>Andrade, Jr, Ildeu</au><au>da Glória Souza, Danielle</au><au>Teixeira, Mauro Martins</au><au>da Silva, Tarcília Aparecida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Lithothamnium sp and calcium supplements in strain- and infection-induced bone resorption</atitle><jtitle>The Angle orthodontist</jtitle><addtitle>Angle Orthod</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>84</volume><issue>6</issue><spage>980</spage><epage>988</epage><pages>980-988</pages><issn>0003-3219</issn><eissn>1945-7103</eissn><abstract>To investigate the effect of Lithothamnium sp (LTT) supplement, a calcium-rich alga widely used for mineral reposition, on strain-induced (orthodontic tooth movement [OTM]) and infection-induced bone resorption (periodontal disease [PD]) in mice.
Mice were divided into two bone resorption models: one with an orthodontic appliance and the other with PD induced by the oral inoculation of Aggregatibacter actinomycetencomitans (Aa). Both groups were fed a regular diet (vehicle), LTT-rich diet (LTT), or calcium-rich diet (CaCO3). Alveolar bone resorption (ABR), the number of osteoclasts, and the levels of tumor necrosis factor α (TNF-α), calcium, and vitamin D3 were evaluated.
The number of osteoclasts was reduced in LTT and CaCO3 mice, which led to diminished OTM and infection-induced alveolar bone loss. In addition, LTT- and calcium-treated groups also presented decreased levels of TNF-α in periodontal tissues and increased levels of calcium in serum.
These results indicate that the LTT supplement influences ABR, probably due to its calcium content, by affecting osteoclast function and local inflammatory response, thus modulating OTM and PD.</abstract><cop>United States</cop><pub>Edward H Angle Education and Research Foundation, Inc</pub><pmid>24731063</pmid><doi>10.2319/080313-579.1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acid Phosphatase - analysis Aggregatibacter actinomycetemcomitans - physiology Alveolar Bone Loss - blood Alveolar Bone Loss - microbiology Alveolar Bone Loss - prevention & control Alveolar Process - drug effects Animals Bone Density Conservation Agents - therapeutic use Calcitriol - blood Calcium - blood Calcium Carbonate - therapeutic use Calcium, Dietary - therapeutic use Cell Count Dietary Supplements Disease Models, Animal Isoenzymes - analysis Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Original Osteoclasts - drug effects Osteoclasts - pathology Pasteurellaceae Infections - microbiology Periodontal Diseases - microbiology Rhodophyta - chemistry Tartrate-Resistant Acid Phosphatase Tooth Movement Techniques - adverse effects Tooth Movement Techniques - instrumentation Tumor Necrosis Factor-alpha - analysis |
| title | Effect of Lithothamnium sp and calcium supplements in strain- and infection-induced bone resorption |
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