METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression

Mis-regulated epigenetic modifications in RNAs are associated with human cancers. The transfer RNAs (tRNAs) are the most heavily modified RNA species in cells; however, little is known about the functions of tRNA modifications in cancers. In this study, we uncovered that the expression levels of tRN...

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Veröffentlicht in:	Molecular therapy 2021-12, Vol.29 (12), p.3422-3435
Hauptverfasser:	Ma, Jieyi, Han, Hui, Huang, Ying, Yang, Chunlong, Zheng, Siyi, Cai, Tiancai, Bi, Jiong, Huang, Xiaohui, Liu, Ruiming, Huang, Libin, Luo, Yifeng, Li, Wen, Lin, Shuibin
Format:	Artikel
Sprache:	eng
Schlagworte:	lung cancer m7G METTL1 N7-methylguanosine Original translation tRNA modification WDR4
Online-Zugang:	Volltext
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