Hyperfluorescence Imaging of Kidney Cancer Enabled by Renal Secretion Pathway Dependent Efflux Transport

Renal tubular secretion is an active efflux pathway for the kidneys to remove molecules but has yet to be used to enhance kidney cancer targeting. We report indocyanine green (ICG) conjugated with a 2100 Da PEG molecule (ICG‐PEG45) as a renal‐tubule‐secreted near‐infrared‐emitting fluorophore for hy...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-01, Vol.60 (1), p.351-359
Hauptverfasser:	Du, Bujie, Chong, Yue, Jiang, Xingya, Yu, Mengxiao, Lo, U‐Gling, Dang, Andrew, Chen, Yu‐An, Li, Siqing, Hernandez, Elizabeth, Lin, Jason C., Hsieh, Jer‐Tsong, Zheng, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Efflux Fluorescent Dyes - therapeutic use Glycoproteins Humans imaging agents indocyanine green Indocyanine Green - therapeutic use Kidney cancer Kidney Neoplasms - diagnostic imaging Kidneys Medical imaging Medical treatment PEGylation Proximal tubules renal cell carcinoma Secretion Secretory Pathway - physiology tumor imaging
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