Optical Control of Adenosine-Mediated Pain Modulation

Adenosine receptors (ARs) play many important roles in physiology and have been recognized as potential targets for pain relief. Here, we introduce three photoswitchable adenosine derivatives that function as light-dependent agonists for ARs and confer optical control to these G protein-coupled rece...

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Veröffentlicht in:	Bioconjugate chemistry 2021-09, Vol.32 (9), p.1979-1983
Hauptverfasser:	Hüll, Katharina, Fernández-Dueñas, Víctor, Schönberger, Matthias, López-Cano, Marc, Trauner, Dirk, Ciruela, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - metabolism Adenosine - pharmacology Adenosine deaminase Adenosine receptors Analgesia Analgesics - chemistry Analgesics - pharmacology Animals Communication G protein-coupled receptors Humans Male Mice Optical control Pain Pain - drug therapy Pain perception Receptors Receptors, Purinergic P1 - metabolism
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