A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys
Abstract The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacologi...
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| Veröffentlicht in: | Microscopy 2021-12, Vol.70 (6), p.498-509 |
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| creator | Sato, Takanori Takakura, Aya Lee, Ji-Won Tokunaga, Kazuaki Matsumori, Haruka Takao-Kawabata, Ryoko Iimura, Tadahiro |
| description | Abstract
The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity. |
| doi_str_mv | 10.1093/jmicro/dfab020 |
| format | Article |
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The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity.</description><identifier>ISSN: 2050-5698</identifier><identifier>EISSN: 2050-5701</identifier><identifier>DOI: 10.1093/jmicro/dfab020</identifier><identifier>PMID: 34100544</identifier><language>eng</language><publisher>UK: Oxford University Press</publisher><subject>Animals ; Bone and Bones - diagnostic imaging ; Bone and Bones - drug effects ; Collagen ; Female ; Haplorhini ; Ovariectomy ; Rats ; Teriparatide - pharmacology</subject><ispartof>Microscopy, 2021-12, Vol.70 (6), p.498-509</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Society of Microscopy. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Society of Microscopy.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-63104e20dde6972e22914fde8085cd00096f2d6bbf66b0df6b3d3fc3870b2c4e3</citedby><cites>FETCH-LOGICAL-c534t-63104e20dde6972e22914fde8085cd00096f2d6bbf66b0df6b3d3fc3870b2c4e3</cites><orcidid>0000-0002-1431-0689</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34100544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Takanori</creatorcontrib><creatorcontrib>Takakura, Aya</creatorcontrib><creatorcontrib>Lee, Ji-Won</creatorcontrib><creatorcontrib>Tokunaga, Kazuaki</creatorcontrib><creatorcontrib>Matsumori, Haruka</creatorcontrib><creatorcontrib>Takao-Kawabata, Ryoko</creatorcontrib><creatorcontrib>Iimura, Tadahiro</creatorcontrib><title>A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys</title><title>Microscopy</title><addtitle>Microscopy (Oxf)</addtitle><description>Abstract
The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity.</description><subject>Animals</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - drug effects</subject><subject>Collagen</subject><subject>Female</subject><subject>Haplorhini</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Teriparatide - pharmacology</subject><issn>2050-5698</issn><issn>2050-5701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkU9v3CAQxVHVKomSXHOsOLaHTTDYrH2pFEX9J0XqJT0jDMOW1IYN4JXcz9UP2Nn1JmpP5WLMe_MbmEfIVcWuK9aJm8fRmxRvrNM94-wVOeOsYatmzarXz3vZtafkMudHhqttKlbLE3Iq6oqxpq7PyO9b-jTpUHzRxe-A6qCHOftMo6N9DEAHPcIw6OTLjKJdDk3Eow0EOvgAi-aDnQygPlPrc_HBFGpj9mFzKHMJniYIxsMBXSD5rU7Y02JPO_qANfvfGJBE4w6hYEoc_S9kopAPlDGGnzDnC_LG6SHD5fF7Tr5_-vhw92V1_-3z17vb-5VpRF1WUuBzgTNrQXZrDpx3Ve0stDgIY3EenXTcyr53UvbMOtkLK5wR7Zr13NQgzsmHhbud-hGsgYB3HNQ2-VGnWUXt1b9K8D_UJu5UKwX2Zgh4dwSkiM_PRY0-m_08A8QpK96IjrNWdhVarxcrJppzAvfSpmJqn7Za0lbHtLHg7d-Xe7E_Z4uG94shTtv_wf4AUr69Fg</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Sato, Takanori</creator><creator>Takakura, Aya</creator><creator>Lee, Ji-Won</creator><creator>Tokunaga, Kazuaki</creator><creator>Matsumori, Haruka</creator><creator>Takao-Kawabata, Ryoko</creator><creator>Iimura, Tadahiro</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1431-0689</orcidid></search><sort><creationdate>20211201</creationdate><title>A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys</title><author>Sato, Takanori ; Takakura, Aya ; Lee, Ji-Won ; Tokunaga, Kazuaki ; Matsumori, Haruka ; Takao-Kawabata, Ryoko ; Iimura, Tadahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-63104e20dde6972e22914fde8085cd00096f2d6bbf66b0df6b3d3fc3870b2c4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - drug effects</topic><topic>Collagen</topic><topic>Female</topic><topic>Haplorhini</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Teriparatide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Takanori</creatorcontrib><creatorcontrib>Takakura, Aya</creatorcontrib><creatorcontrib>Lee, Ji-Won</creatorcontrib><creatorcontrib>Tokunaga, Kazuaki</creatorcontrib><creatorcontrib>Matsumori, Haruka</creatorcontrib><creatorcontrib>Takao-Kawabata, Ryoko</creatorcontrib><creatorcontrib>Iimura, Tadahiro</creatorcontrib><collection>Oxford University Press Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Takanori</au><au>Takakura, Aya</au><au>Lee, Ji-Won</au><au>Tokunaga, Kazuaki</au><au>Matsumori, Haruka</au><au>Takao-Kawabata, Ryoko</au><au>Iimura, Tadahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys</atitle><jtitle>Microscopy</jtitle><addtitle>Microscopy (Oxf)</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>70</volume><issue>6</issue><spage>498</spage><epage>509</epage><pages>498-509</pages><issn>2050-5698</issn><eissn>2050-5701</eissn><abstract>Abstract
The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity.</abstract><cop>UK</cop><pub>Oxford University Press</pub><pmid>34100544</pmid><doi>10.1093/jmicro/dfab020</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-1431-0689</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2050-5698 |
| ispartof | Microscopy, 2021-12, Vol.70 (6), p.498-509 |
| issn | 2050-5698 2050-5701 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Bone and Bones - diagnostic imaging Bone and Bones - drug effects Collagen Female Haplorhini Ovariectomy Rats Teriparatide - pharmacology |
| title | A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys |
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