Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage

Biomechanical changes to the collagen fibrillar architecture in articular cartilage are believed to play a crucial role in enabling normal joint function. However, experimentally there is little quantitative knowledge about the structural response of the Type II collagen fibrils in cartilage to cycl...

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Veröffentlicht in:	Acta biomaterialia 2021-12, Vol.136, p.314-326
Hauptverfasser:	Inamdar, Sheetal R, Prévost, Sylvain, Terrill, Nicholas J, Knight, Martin M, Gupta, Himadri S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Arthritis Back pain Biomaterials Biomechanical Phenomena Biomechanics Biomedical materials Cartilage Cartilage diseases Cartilage, Articular Cattle Collagen Collagen (type II) Collagen fibrillar nanomechanics Compression Critical components Cyclic loads Cytokines Degradation Explants Extracellular Matrix Fibrils Full Length IL-1β Image reconstruction Inflammation Joints (anatomy) Organs Orientation effects Osteoarthritis Physics Repeated loading Scattering, Small Angle Stiffness Structural response Synchrotron small-angle x-ray scattering Synchrotrons Tissues Variability X-Ray Diffraction X-ray scattering
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