Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy
Lipoic acid (alpha lipoic acid, thioctic acid) is a popular over-the-counter antioxidant and insulin-mimetic supplement under investigation in a variety of conditions including multiple sclerosis, diabetes, and schizophrenia. Unfortunately, high-grade proteinuria was an unexpected adverse event spec...
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| Veröffentlicht in: | Kidney international 2021-12, Vol.100 (6), p.1208-1213 |
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| container_title | Kidney international |
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| creator | Spain, Rebecca I. Andeen, Nicole K. Gibson, Pamela C. Samuels, Mary H. Morris, Cynthia D. Solomon, Andrew J. Solomon, Richard Waslo, Carin Avasare, Rupali S. |
| description | Lipoic acid (alpha lipoic acid, thioctic acid) is a popular over-the-counter antioxidant and insulin-mimetic supplement under investigation in a variety of conditions including multiple sclerosis, diabetes, and schizophrenia. Unfortunately, high-grade proteinuria was an unexpected adverse event specific to the treatment arm of our clinical trial investigating lipoic acid supplementation in patients with multiple sclerosis. This observation led to detection of similar patients in our nephrology practice. Here, we describe four biopsy-proven cases of neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy following lipoic acid supplementation and a fifth suspected case. Discontinuation of lipoic acid and supportive therapy resulted in remission.
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| doi_str_mv | 10.1016/j.kint.2021.10.010 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1016/j.kint.2021.10.010</identifier><identifier>PMID: 34662650</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>albuminuria ; Calcium-Binding Proteins ; Dietary Supplements ; EGF Family of Proteins ; glomerulonephritis ; Glomerulonephritis, Membranous - diagnosis ; Glomerulonephritis, Membranous - drug therapy ; Humans ; kidney biopsy ; kidney pathology ; lipoic acid ; membranous nephropathy ; nephrotic syndrome ; proteinuria ; Proteinuria - chemically induced ; Proteinuria - drug therapy ; Thioctic Acid - adverse effects</subject><ispartof>Kidney international, 2021-12, Vol.100 (6), p.1208-1213</ispartof><rights>2021</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-785e1192a52a1299466c80279a622baf1510961d96886bb47ae638ab1ded99633</citedby><cites>FETCH-LOGICAL-c455t-785e1192a52a1299466c80279a622baf1510961d96886bb47ae638ab1ded99633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34662650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spain, Rebecca I.</creatorcontrib><creatorcontrib>Andeen, Nicole K.</creatorcontrib><creatorcontrib>Gibson, Pamela C.</creatorcontrib><creatorcontrib>Samuels, Mary H.</creatorcontrib><creatorcontrib>Morris, Cynthia D.</creatorcontrib><creatorcontrib>Solomon, Andrew J.</creatorcontrib><creatorcontrib>Solomon, Richard</creatorcontrib><creatorcontrib>Waslo, Carin</creatorcontrib><creatorcontrib>Avasare, Rupali S.</creatorcontrib><title>Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Lipoic acid (alpha lipoic acid, thioctic acid) is a popular over-the-counter antioxidant and insulin-mimetic supplement under investigation in a variety of conditions including multiple sclerosis, diabetes, and schizophrenia. Unfortunately, high-grade proteinuria was an unexpected adverse event specific to the treatment arm of our clinical trial investigating lipoic acid supplementation in patients with multiple sclerosis. This observation led to detection of similar patients in our nephrology practice. Here, we describe four biopsy-proven cases of neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy following lipoic acid supplementation and a fifth suspected case. Discontinuation of lipoic acid and supportive therapy resulted in remission.
[Display omitted]</description><subject>albuminuria</subject><subject>Calcium-Binding Proteins</subject><subject>Dietary Supplements</subject><subject>EGF Family of Proteins</subject><subject>glomerulonephritis</subject><subject>Glomerulonephritis, Membranous - diagnosis</subject><subject>Glomerulonephritis, Membranous - drug therapy</subject><subject>Humans</subject><subject>kidney biopsy</subject><subject>kidney pathology</subject><subject>lipoic acid</subject><subject>membranous nephropathy</subject><subject>nephrotic syndrome</subject><subject>proteinuria</subject><subject>Proteinuria - chemically induced</subject><subject>Proteinuria - drug therapy</subject><subject>Thioctic Acid - adverse effects</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFOGzEQtVARBMoP9FDtsT1ssL2xY0tVpQpBQVrRS3u2Zu0JcciuV7YD4lCp_8Af8iV1FED00pPHz_Pe-M0j5AOjU0aZPF1Nb_2Qp5xyVoApZXSPTJjgTc3mQrwjE0qVqLlo1CE5SmlFy1039IAcNjMpuRR0Qn63fgzeVmC9q9JmHNfY45Ah-zBUkFKwHjK66t7nZTXgJsK6wtE7jH2pbmK4L_gCbA6xXvtbrFj16fq8bdnnpz-Pb_g99l2EIWxSURmXMYyQlw_vyf4C1glPns9j8uvi_OfZZd3--H519q2t7UyIXM-VQMY0B8GBca3L762ifK5Bct7BgglGtWROS6Vk183mgLJR0DGHTmvZNMfk60533HQ9OlscFiNmjL6H-GACePPvy-CX5ibcGSW5UkIVAb4TsDGkFHHxymXUbMMwK7MNw2zD2GIljEL6-HbqK-Vl-6Xhy64Bi_c7j9Ek63Gw6HxEm40L_n_6fwHpmp8o</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Spain, Rebecca I.</creator><creator>Andeen, Nicole K.</creator><creator>Gibson, Pamela C.</creator><creator>Samuels, Mary H.</creator><creator>Morris, Cynthia D.</creator><creator>Solomon, Andrew J.</creator><creator>Solomon, Richard</creator><creator>Waslo, Carin</creator><creator>Avasare, Rupali S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20211201</creationdate><title>Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy</title><author>Spain, Rebecca I. ; Andeen, Nicole K. ; Gibson, Pamela C. ; Samuels, Mary H. ; Morris, Cynthia D. ; Solomon, Andrew J. ; Solomon, Richard ; Waslo, Carin ; Avasare, Rupali S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-785e1192a52a1299466c80279a622baf1510961d96886bb47ae638ab1ded99633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>albuminuria</topic><topic>Calcium-Binding Proteins</topic><topic>Dietary Supplements</topic><topic>EGF Family of Proteins</topic><topic>glomerulonephritis</topic><topic>Glomerulonephritis, Membranous - diagnosis</topic><topic>Glomerulonephritis, Membranous - drug therapy</topic><topic>Humans</topic><topic>kidney biopsy</topic><topic>kidney pathology</topic><topic>lipoic acid</topic><topic>membranous nephropathy</topic><topic>nephrotic syndrome</topic><topic>proteinuria</topic><topic>Proteinuria - chemically induced</topic><topic>Proteinuria - drug therapy</topic><topic>Thioctic Acid - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spain, Rebecca I.</creatorcontrib><creatorcontrib>Andeen, Nicole K.</creatorcontrib><creatorcontrib>Gibson, Pamela C.</creatorcontrib><creatorcontrib>Samuels, Mary H.</creatorcontrib><creatorcontrib>Morris, Cynthia D.</creatorcontrib><creatorcontrib>Solomon, Andrew J.</creatorcontrib><creatorcontrib>Solomon, Richard</creatorcontrib><creatorcontrib>Waslo, Carin</creatorcontrib><creatorcontrib>Avasare, Rupali S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spain, Rebecca I.</au><au>Andeen, Nicole K.</au><au>Gibson, Pamela C.</au><au>Samuels, Mary H.</au><au>Morris, Cynthia D.</au><au>Solomon, Andrew J.</au><au>Solomon, Richard</au><au>Waslo, Carin</au><au>Avasare, Rupali S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>100</volume><issue>6</issue><spage>1208</spage><epage>1213</epage><pages>1208-1213</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><abstract>Lipoic acid (alpha lipoic acid, thioctic acid) is a popular over-the-counter antioxidant and insulin-mimetic supplement under investigation in a variety of conditions including multiple sclerosis, diabetes, and schizophrenia. Unfortunately, high-grade proteinuria was an unexpected adverse event specific to the treatment arm of our clinical trial investigating lipoic acid supplementation in patients with multiple sclerosis. This observation led to detection of similar patients in our nephrology practice. Here, we describe four biopsy-proven cases of neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy following lipoic acid supplementation and a fifth suspected case. Discontinuation of lipoic acid and supportive therapy resulted in remission.
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| language | eng |
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| subjects | albuminuria Calcium-Binding Proteins Dietary Supplements EGF Family of Proteins glomerulonephritis Glomerulonephritis, Membranous - diagnosis Glomerulonephritis, Membranous - drug therapy Humans kidney biopsy kidney pathology lipoic acid membranous nephropathy nephrotic syndrome proteinuria Proteinuria - chemically induced Proteinuria - drug therapy Thioctic Acid - adverse effects |
| title | Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy |
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