Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test
A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ f...
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| Veröffentlicht in: | Internal Medicine 2021/11/01, Vol.60(21), pp.3481-3483 |
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| container_title | Internal Medicine |
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| creator | Yamaba, Yusuke Takakuwa, Osamu Ida, Chiaki Saito, Manami Kawae, Daisuke Yoshihara, Misuzu Kunii, Eiji Imaeda, Kenro Tatsuno, Ichiro Hasegawa, Tadao Akita, Kenji |
| description | A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient. |
| doi_str_mv | 10.2169/internalmedicine.6290-20 |
| format | Article |
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Med.</addtitle><description>A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient.</description><subject>Arthralgia</subject><subject>Blood culture</subject><subject>Case Report</subject><subject>csrR</subject><subject>Diarrhea</subject><subject>emm</subject><subject>Genotypes</subject><subject>Internal medicine</subject><subject>NADase</subject><subject>Sepsis</subject><subject>Septic shock</subject><subject>Streptococcal toxic shock syndrome</subject><subject>Streptococcus</subject><subject>STSS</subject><subject>Toxic shock syndrome</subject><subject>Uterine cancer</subject><subject>Virulence factors</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNptkc2O0zAUhS0EYsrAO1hincG-dn68QRoVKCONNIt21pbr3ExSEjs4zkBfgOfGUasKEJt7Jft8x0c-hFDOboAX6kPnIgZn-gHrznYObwpQLAP2gqy4kCorQeQvyYopXmWQxhV5M00HxkRVKnhNroRQSkohV-TXNgYco7feWtPTnf_ZWbptvf1Gt0dXBz8gvXP1bLGm-yPdBD-P9Jb-Qc0T_dHFlsYWKQ4DVHSDzsfjiHTXmkg_4TP2fky8aVJqauhjWik0XRtn08EOp_iWvGpMP-G7874mj18-79Zfs_uHzd369j6zMoeYyWbPOXAFTckU5nVdihxLFMzIprGF4ozvGbcloAAFhSpAVE3FSy4FgkQhrsnHk-8479PnWXQxmF6PoRtMOGpvOv33jeta_eSfdVVAWXGVDN6fDYL_Pqfk-uDnpYpJQ664hKIQRVJVJ5UNfpoCNpcXONNLg_rfBvXSoAaW0IcTepiiecILaELsbI__ARfHZZ4dLkrbmqDRid98_7GX</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Yamaba, Yusuke</creator><creator>Takakuwa, Osamu</creator><creator>Ida, Chiaki</creator><creator>Saito, Manami</creator><creator>Kawae, Daisuke</creator><creator>Yoshihara, Misuzu</creator><creator>Kunii, Eiji</creator><creator>Imaeda, Kenro</creator><creator>Tatsuno, Ichiro</creator><creator>Hasegawa, Tadao</creator><creator>Akita, Kenji</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20211101</creationdate><title>Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test</title><author>Yamaba, Yusuke ; Takakuwa, Osamu ; Ida, Chiaki ; Saito, Manami ; Kawae, Daisuke ; Yoshihara, Misuzu ; Kunii, Eiji ; Imaeda, Kenro ; Tatsuno, Ichiro ; Hasegawa, Tadao ; Akita, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-4fb112192f709e5dd735e7e30a4ffc69101b01c72e3292696238f817143e24e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Arthralgia</topic><topic>Blood culture</topic><topic>Case Report</topic><topic>csrR</topic><topic>Diarrhea</topic><topic>emm</topic><topic>Genotypes</topic><topic>Internal medicine</topic><topic>NADase</topic><topic>Sepsis</topic><topic>Septic shock</topic><topic>Streptococcal toxic shock syndrome</topic><topic>Streptococcus</topic><topic>STSS</topic><topic>Toxic shock syndrome</topic><topic>Uterine cancer</topic><topic>Virulence factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamaba, Yusuke</creatorcontrib><creatorcontrib>Takakuwa, Osamu</creatorcontrib><creatorcontrib>Ida, Chiaki</creatorcontrib><creatorcontrib>Saito, Manami</creatorcontrib><creatorcontrib>Kawae, Daisuke</creatorcontrib><creatorcontrib>Yoshihara, Misuzu</creatorcontrib><creatorcontrib>Kunii, Eiji</creatorcontrib><creatorcontrib>Imaeda, Kenro</creatorcontrib><creatorcontrib>Tatsuno, Ichiro</creatorcontrib><creatorcontrib>Hasegawa, Tadao</creatorcontrib><creatorcontrib>Akita, Kenji</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaba, Yusuke</au><au>Takakuwa, Osamu</au><au>Ida, Chiaki</au><au>Saito, Manami</au><au>Kawae, Daisuke</au><au>Yoshihara, Misuzu</au><au>Kunii, Eiji</au><au>Imaeda, Kenro</au><au>Tatsuno, Ichiro</au><au>Hasegawa, Tadao</au><au>Akita, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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| subjects | Arthralgia Blood culture Case Report csrR Diarrhea emm Genotypes Internal medicine NADase Sepsis Septic shock Streptococcal toxic shock syndrome Streptococcus STSS Toxic shock syndrome Uterine cancer Virulence factors |
| title | Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test |
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