Persistent Working Memory Impairment Associated with Cerebral Infarction in the Anterior Cingulate Cortex: A Case Report and a Literature Review
A 52-year-old man experienced sudden-onset global amnesia and left limb ataxia. An embolism of the right anterior cerebral artery resulted in anterior cingulate cortex (ACC) infarction, and working memory dysfunction persisted. The ACC, prefrontal cortex, and bilateral superior parietal lobule exhib...
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| Veröffentlicht in: | Internal Medicine 2021/11/01, Vol.60(21), pp.3473-3476 |
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| container_title | Internal Medicine |
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| creator | Kobayashi, Yuya Morizumi, Teruya Nagamatsu, Kiyoshiro Shimizu, Yusaku Kamiya, Keisuke Sasaki, Tetsuo Sato, Atsushi |
| description | A 52-year-old man experienced sudden-onset global amnesia and left limb ataxia. An embolism of the right anterior cerebral artery resulted in anterior cingulate cortex (ACC) infarction, and working memory dysfunction persisted. The ACC, prefrontal cortex, and bilateral superior parietal lobule exhibited decreased activity on single-photon emission computed tomography (SPECT). The ACC handles working memory formation and is essential for the executive function. The areas showing a decreased activity on SPECT were responsible for the working memory, which corresponded to the observed symptoms. This is the first case in which limited ACC infarction resulted in permanent working memory dysfunction, and SPECT revealed the decreasing working memory in the associated region. |
| doi_str_mv | 10.2169/internalmedicine.6927-20 |
| format | Article |
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An embolism of the right anterior cerebral artery resulted in anterior cingulate cortex (ACC) infarction, and working memory dysfunction persisted. The ACC, prefrontal cortex, and bilateral superior parietal lobule exhibited decreased activity on single-photon emission computed tomography (SPECT). The ACC handles working memory formation and is essential for the executive function. The areas showing a decreased activity on SPECT were responsible for the working memory, which corresponded to the observed symptoms. This is the first case in which limited ACC infarction resulted in permanent working memory dysfunction, and SPECT revealed the decreasing working memory in the associated region.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.6927-20</identifier><identifier>PMID: 33994436</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Amnesia ; anterior cingulate cortex ; Ataxia ; Case Report ; Cerebral infarction ; cingulate gyrus ; Computed tomography ; Cortex (cingulate) ; Cortex (parietal) ; Embolism ; Executive function ; Internal medicine ; Literature reviews ; Prefrontal cortex ; Short term memory ; Single photon emission computed tomography ; stroke ; Superior parietal lobule ; working memory</subject><ispartof>Internal Medicine, 2021/11/01, Vol.60(21), pp.3473-3476</ispartof><rights>2021 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><rights>Copyright © 2021 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c555t-868bbdaded8f3e519946521e2a960195db531a8d8ff5c18b9b7957e0eba196093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627815/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627815/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33994436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayashi, Yuya</creatorcontrib><creatorcontrib>Morizumi, Teruya</creatorcontrib><creatorcontrib>Nagamatsu, Kiyoshiro</creatorcontrib><creatorcontrib>Shimizu, Yusaku</creatorcontrib><creatorcontrib>Kamiya, Keisuke</creatorcontrib><creatorcontrib>Sasaki, Tetsuo</creatorcontrib><creatorcontrib>Sato, Atsushi</creatorcontrib><title>Persistent Working Memory Impairment Associated with Cerebral Infarction in the Anterior Cingulate Cortex: A Case Report and a Literature Review</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 52-year-old man experienced sudden-onset global amnesia and left limb ataxia. An embolism of the right anterior cerebral artery resulted in anterior cingulate cortex (ACC) infarction, and working memory dysfunction persisted. The ACC, prefrontal cortex, and bilateral superior parietal lobule exhibited decreased activity on single-photon emission computed tomography (SPECT). The ACC handles working memory formation and is essential for the executive function. The areas showing a decreased activity on SPECT were responsible for the working memory, which corresponded to the observed symptoms. This is the first case in which limited ACC infarction resulted in permanent working memory dysfunction, and SPECT revealed the decreasing working memory in the associated region.</description><subject>Amnesia</subject><subject>anterior cingulate cortex</subject><subject>Ataxia</subject><subject>Case Report</subject><subject>Cerebral infarction</subject><subject>cingulate gyrus</subject><subject>Computed tomography</subject><subject>Cortex (cingulate)</subject><subject>Cortex (parietal)</subject><subject>Embolism</subject><subject>Executive function</subject><subject>Internal medicine</subject><subject>Literature reviews</subject><subject>Prefrontal cortex</subject><subject>Short term memory</subject><subject>Single photon emission computed tomography</subject><subject>stroke</subject><subject>Superior parietal lobule</subject><subject>working memory</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNptkduO0zAQhi0EYsvCKyBL3HCTxYc4sblAqiIOlYoWIRCXlpNMW5fELrazy74Fj4yjlgpW3IylmW_-mfGPEKbkitFKvbIuQXBmGKG3nXVwVSlWF4w8QAvKS1XUjIuHaEEUlQXL4QI9iXFPCJe1Yo_RBedKlSWvFujXJwjRxgQu4W8-fLduiz_C6MMdXo0HY8M4V5Yx-s6aBD2-tWmHGwjQBjPglduY0CXrHbYOpx3g5bya9QE3WWoacg9ufEjw8zVe4sZEwJ_hkBPYuB4bvLYZN2kKc_7Gwu1T9GhjhgjPTu8l-vru7ZfmQ7G-fr9qluuiE0KkQlaybXvTQy83HATN91SCUWBGVYQq0beCUyNzdSM6KlvV1krUQKA1NBOKX6I3R93D1OZv7PKZ-SB9CHY04U57Y_W_FWd3eutvtKxYLanIAi9PAsH_mCAmPdrYwTAYB36KmgkmSy4Yoxl9cQ_d-2n2b6YULZlkZBaUR6oLPsYAm_MylOjZdn3fdj3brhnJrc__Pubc-MfnDFwfgX1MZgtnwIRkuwH-ozyPnONpxJnsdiZocPw3mAzOwA</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Kobayashi, Yuya</creator><creator>Morizumi, Teruya</creator><creator>Nagamatsu, Kiyoshiro</creator><creator>Shimizu, Yusaku</creator><creator>Kamiya, Keisuke</creator><creator>Sasaki, Tetsuo</creator><creator>Sato, Atsushi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211101</creationdate><title>Persistent Working Memory Impairment Associated with Cerebral Infarction in the Anterior Cingulate Cortex: A Case Report and a Literature Review</title><author>Kobayashi, Yuya ; Morizumi, Teruya ; Nagamatsu, Kiyoshiro ; Shimizu, Yusaku ; Kamiya, Keisuke ; Sasaki, Tetsuo ; Sato, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-868bbdaded8f3e519946521e2a960195db531a8d8ff5c18b9b7957e0eba196093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amnesia</topic><topic>anterior cingulate cortex</topic><topic>Ataxia</topic><topic>Case Report</topic><topic>Cerebral infarction</topic><topic>cingulate gyrus</topic><topic>Computed tomography</topic><topic>Cortex (cingulate)</topic><topic>Cortex (parietal)</topic><topic>Embolism</topic><topic>Executive function</topic><topic>Internal medicine</topic><topic>Literature reviews</topic><topic>Prefrontal cortex</topic><topic>Short term memory</topic><topic>Single photon emission computed tomography</topic><topic>stroke</topic><topic>Superior parietal lobule</topic><topic>working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Yuya</creatorcontrib><creatorcontrib>Morizumi, Teruya</creatorcontrib><creatorcontrib>Nagamatsu, Kiyoshiro</creatorcontrib><creatorcontrib>Shimizu, Yusaku</creatorcontrib><creatorcontrib>Kamiya, Keisuke</creatorcontrib><creatorcontrib>Sasaki, Tetsuo</creatorcontrib><creatorcontrib>Sato, Atsushi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Yuya</au><au>Morizumi, Teruya</au><au>Nagamatsu, Kiyoshiro</au><au>Shimizu, Yusaku</au><au>Kamiya, Keisuke</au><au>Sasaki, Tetsuo</au><au>Sato, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent Working Memory Impairment Associated with Cerebral Infarction in the Anterior Cingulate Cortex: A Case Report and a Literature Review</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>60</volume><issue>21</issue><spage>3473</spage><epage>3476</epage><pages>3473-3476</pages><artnum>6927-20</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 52-year-old man experienced sudden-onset global amnesia and left limb ataxia. An embolism of the right anterior cerebral artery resulted in anterior cingulate cortex (ACC) infarction, and working memory dysfunction persisted. The ACC, prefrontal cortex, and bilateral superior parietal lobule exhibited decreased activity on single-photon emission computed tomography (SPECT). The ACC handles working memory formation and is essential for the executive function. The areas showing a decreased activity on SPECT were responsible for the working memory, which corresponded to the observed symptoms. This is the first case in which limited ACC infarction resulted in permanent working memory dysfunction, and SPECT revealed the decreasing working memory in the associated region.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>33994436</pmid><doi>10.2169/internalmedicine.6927-20</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amnesia anterior cingulate cortex Ataxia Case Report Cerebral infarction cingulate gyrus Computed tomography Cortex (cingulate) Cortex (parietal) Embolism Executive function Internal medicine Literature reviews Prefrontal cortex Short term memory Single photon emission computed tomography stroke Superior parietal lobule working memory |
| title | Persistent Working Memory Impairment Associated with Cerebral Infarction in the Anterior Cingulate Cortex: A Case Report and a Literature Review |
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