Strategies for late phase preclinical and early clinical trials of senolytics

•Accumulation of senescent cells is associated with age-related diseases and disorders.•Senolytics and senomorphics are potential interventions for delaying, preventing, or treating age-related dysfunction.•Senolytics show efficacy in pre-clinical and early clinical trials.•Running trials in paralle...

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Veröffentlicht in:	Mechanisms of ageing and development 2021-12, Vol.200, p.111591-111591, Article 111591
Hauptverfasser:	Wissler Gerdes, Erin O., Misra, Avanish, Netto, Jair Machado Espindola, Tchkonia, Tamar, Kirkland, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - drug effects Aging - physiology Animals Cellular Senescence - drug effects Clinical Trials as Topic - methods Dasatinib Drug Development - methods Drug Evaluation, Preclinical - methods Fisetin Humans Models, Animal Quercetin Senolytics Senotherapeutics - classification Senotherapeutics - pharmacology Translational Geroscience Network Unitary Theory of Fundamental Aging Processes
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