Mouse background genetics in biomedical research: The devil's in the details

Background Genetically modified mice are used widely to explore mechanisms in most biomedical fields—including transfusion. Concluding that a gene modification is responsible for a phenotypic change assumes no other differences between the gene‐modified and wild‐type mice besides the targetted gene....

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2021-10, Vol.61 (10), p.3017-3025
Hauptverfasser:	Hay, Ariel M., Howie, Heather L., Gorham, James D., D'Alessandro, Angelo, Spitalnik, Steven L., Hudson, Krystalyn E., Zimring, James C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome 1 Contamination Design modifications Embryo cells Experimentation Genetic modification Genetics Genotyping Heredity Injury analysis Lipid peroxidation Lipids Medical research Metabolism Metabolomics Norms Oxidation Single-nucleotide polymorphism Stem cell transplantation Stem cells Strains (organisms) Transfusion
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