Reduction of Oxidative Stress in Peripheral Blood Mononuclear Cells Attenuates the Inflammatory Response of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

The production and oxidation mechanism of reactive oxygen species (ROS) are out of balance in rheumatoid arthritis (RA). However, the correlation between ROS and T cell subsets in RA remains unclear. Peripheral blood mononuclear cells (PBMCs) from patients with RA (n = 40) and healthy controls (n =...

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Veröffentlicht in:	International journal of molecular sciences 2021-11, Vol.22 (22), p.12411
Hauptverfasser:	Lee, Ha-Reum, Yoo, Su-Jin, Kim, Jinhyun, Park, Chan Keol, Kang, Seong Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Arthritis Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Blood Case-Control Studies Cells, Cultured Chemokines Coculture Techniques Cytokines Cytokines - metabolism Disease Female Fibroblasts Fibroblasts - immunology Gene expression Homeostasis Humans Hyperplasia Immunoregulation Inflammation Inflammation - metabolism Inflammatory response Leukocytes (mononuclear) Lymphocytes Lymphocytes T Male Middle Aged Mitochondria Mitochondria - metabolism Oxidation Oxidative Stress Pathogenesis Peripheral blood mononuclear cells Polymerase chain reaction Population Reactive oxygen species Reactive Oxygen Species - metabolism Rheumatoid arthritis Severity of Illness Index Synovial fluid Synovial Fluid - metabolism Synoviocytes Synoviocytes - immunology T cell receptors T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - immunology Tumor necrosis factor-TNF
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