Flavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cells

Phloretin (a flavonoid abundant in apple), has antioxidant, anti-inflammatory, and glucose-transporter inhibitory properties. Thus, it has interesting pharmacological and nutraceutical potential. Bone-marrow mesenchymal stem cells (MSC) have high differentiation capacity, being essential for maintai...

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Veröffentlicht in:	Nutrients 2021-11, Vol.13 (11), p.4185, Article 4185
Hauptverfasser:	Casado-Diaz, Antonio, Rodriguez-Ramos, Angel, Torrecillas-Baena, Barbara, Dorado, Gabriel, Quesada-Gomez, Jose Manuel, Galvez-Moreno, Maria Angeles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipogenesis Adipose tissue Aging Antioxidants Apoptosis Biomedical materials Body fat bone Bone growth Bone marrow Bone mass Bone remodeling Bone turnover Cell differentiation Diabetes Differentiation Epidemics Flavonoids Functional foods & nutraceuticals Gene expression Genes Glucose Glucose transporter Homeostasis human mesenchymal stem cells Inflammation Life Sciences & Biomedicine Lipids Mesenchyme Nutrition & Dietetics Obesity Osteoclastogenesis Osteoporosis Osteoprotegerin phloretin Protein biosynthesis Protein synthesis Regenerative medicine Science & Technology Stem cells TRANCE protein β-Catenin
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