Ets1 Promotes the Differentiation of Post-Selected iNKT Cells through Regulation of the Expression of Vα14Jα18 T Cell Receptor and PLZF

The transcription factor Ets1 is essential for the development/differentiation of invariant Natural Killer T (iNKT) cells at multiple stages. However, its mechanisms of action and target genes in iNKT cells are still elusive. Here, we show that Ets1 is required for the optimal expression of the Vα14...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2021-11, Vol.22 (22), p.12199
Hauptverfasser:	Chuang, Ya-Ting, Chuang, Wan-Chu, Liu, Chih-Chun, Liu, Chia-Wei, Huang, Yu-Wen, Yang, Huang-Yu, Ho, I-Cheng, Tai, Tzong-Shyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell activation Cell differentiation Cell Differentiation - genetics Cell Differentiation - immunology Cell proliferation Cytokines Differentiation Ets-1 protein Gene expression Gene Expression Regulation - immunology Genomes Homeostasis Leukocytes Lymphocytes Lymphocytes T Mice Mice, Knockout Natural killer cells Natural Killer T-Cells - immunology Promyelocytic Leukemia Zinc Finger Protein - genetics Promyelocytic Leukemia Zinc Finger Protein - immunology Proto-Oncogene Protein c-ets-1 - genetics Proto-Oncogene Protein c-ets-1 - immunology Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology T cell receptors Thymus Transcriptomics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!