Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide

Currently, the clinical impact of cell therapy after a myocardial infarction (MI) is limited by low cell engraftment due to low cell retention, cell death in inflammatory and poor angiogenic infarcted areas, secondary migration. Cells interact with their microenvironment through integrin mechanorece...

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Veröffentlicht in:	International journal of molecular sciences 2021-11, Vol.22 (22), p.12563
Hauptverfasser:	Schussler, Olivier, Falcoz, Pierre E, Chachques, Juan C, Alifano, Marco, Lecarpentier, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Biocompatible Materials - chemistry Biocompatible Materials - therapeutic use Cardiomyocytes Cell death Cell Differentiation - drug effects Cell proliferation Cell therapy Collagen Collagen - chemistry Collagen - therapeutic use Contractility Fibrin Freeze drying Gelatin Heart failure Humans Hydrogels Hydrogels - therapeutic use Inflammation Integrins Ligands Mechanoreceptors Microenvironments Myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - pathology Myocardial Infarction - therapy Peptides Peptides - genetics Peptides - therapeutic use Polymers Printing, Three-Dimensional Production methods Proteins Retention Review Scaffolds Stem cells Tissue Engineering Tissue Scaffolds - chemistry Transplants & implants Ventricle
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