Mechanisms of Nucleosome Reorganization by PARP1

Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme involved in DNA repair, chromatin organization and transcription. During transcription initiation, PARP1 interacts with gene promoters where it binds to nucleosomes, replaces linker histone H1 and participates in gene regulation. However, the mechan...

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Veröffentlicht in:	International journal of molecular sciences 2021-11, Vol.22 (22), p.12127
Hauptverfasser:	Maluchenko, Natalya V, Nilov, Dmitry K, Pushkarev, Sergey V, Kotova, Elena Y, Gerasimova, Nadezhda S, Kirpichnikov, Mikhail P, Langelier, Marie-France, Pascal, John M, Akhtar, Md Sohail, Feofanov, Alexey V, Studitsky, Vasily M
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Catalytic activity Chromatin Chromatin - genetics Deoxyribonucleic acid DNA DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Enzymes Gene Expression Regulation - genetics Gene regulation Histone H1 Histones Histones - genetics Humans Microscopy Molecular dynamics Molecular Dynamics Simulation Nucleosomes Nucleosomes - genetics Poly (ADP-Ribose) Polymerase-1 - genetics Poly(ADP-ribose) Poly(ADP-ribose) polymerase Promoter Regions, Genetic - genetics Proteins Repair Ribose Stem cells Transcription initiation
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