Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?
Osteosarcoma (OS) is a skeletal tumor affecting mainly children and adolescents. The presence of distance metastasis is frequent and it is localized preferentially to the lung, representing the main reason for death among patients. The therapeutic approaches are based on surgery and chemotherapeutic...
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| Veröffentlicht in: | International journal of molecular sciences 2021-11, Vol.22 (22), p.12586 |
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| description | Osteosarcoma (OS) is a skeletal tumor affecting mainly children and adolescents. The presence of distance metastasis is frequent and it is localized preferentially to the lung, representing the main reason for death among patients. The therapeutic approaches are based on surgery and chemotherapeutics. However, the drug resistance and the side effects associated with the chemotherapy require the identification of new therapeutic approaches. The understanding of the complex biological scenario of the osteosarcoma will open the way for the identification of new targets for its treatment. Recently, a great interest of scientific community is for extracellular vesicles (EVs), that are released in the tumor microenvironment and are important regulators of tumor proliferation and the metastatic process. At the same time, circulating extracellular vesicles can be exploited as diagnostic and prognostic biomarkers, and they can be loaded with drugs as a new therapeutic approach for osteosarcoma patients. Thus, the characterization of OS-related EVs could represent a way to convert these vesicles from antagonists for human health into therapeutic and/or diagnostic agents. |
| doi_str_mv | 10.3390/ijms222212586 |
| format | Article |
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The presence of distance metastasis is frequent and it is localized preferentially to the lung, representing the main reason for death among patients. The therapeutic approaches are based on surgery and chemotherapeutics. However, the drug resistance and the side effects associated with the chemotherapy require the identification of new therapeutic approaches. The understanding of the complex biological scenario of the osteosarcoma will open the way for the identification of new targets for its treatment. Recently, a great interest of scientific community is for extracellular vesicles (EVs), that are released in the tumor microenvironment and are important regulators of tumor proliferation and the metastatic process. At the same time, circulating extracellular vesicles can be exploited as diagnostic and prognostic biomarkers, and they can be loaded with drugs as a new therapeutic approach for osteosarcoma patients. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Acidosis Amputation Angiogenesis Antagonists Antineoplastic Agents - adverse effects Biomedical materials Bone cancer Bones Cell Movement - drug effects Cell Movement - genetics Cell Proliferation - drug effects Chemical compounds Chemokines Chemotherapy Diagnostic agents Diagnostic systems Drug resistance Drug Resistance - genetics Extracellular vesicles Extracellular Vesicles - chemistry Extracellular Vesicles - genetics Gene Expression Regulation, Neoplastic - drug effects Humans Metastases Metastasis Neoplasm Metastasis Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - genetics Pain Patients Pharmacology Review Sarcoma Stem cells Tumor microenvironment Tumor Microenvironment - drug effects Tumors Vascular endothelial growth factor Vesicles |
| title | Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents? |
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