Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

The selection of technological parameters for nanoparticle formulation represents a complicated development phase. Therefore, the statistical analysis based on Box-Behnken methodology is widely used to optimize technological processes, including poly(lactic-co-glycolic acid) nanoparticle formulation...

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Veröffentlicht in:	International journal of molecular sciences 2021-11, Vol.22 (22), p.12261
Hauptverfasser:	Mollaeva, Mariia R, Yabbarov, Nikita, Sokol, Maria, Chirkina, Margarita, Mollaev, Murad D, Zabolotskii, Artur, Seregina, Irina, Bolshov, Mikhail, Kaplun, Alexander, Nikolskaya, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor activity Bioaccumulation Cancer therapies Cell Line, Tumor Cell Survival - drug effects Cobalt Coordination Complexes - chemistry Coordination Complexes - pharmacokinetics Coordination Complexes - pharmacology Design factors Design optimization Drug delivery systems Drug Liberation Experiments Female Fourier analysis Glycolic acid HeLa Cells Hemolysis - drug effects Humans Hydrophobicity Infrared spectroscopy Light diffraction Light scattering Manganese Mathematical models MCF-7 Cells Medical research Metalloporphyrins - chemistry Metalloporphyrins - pharmacokinetics Metalloporphyrins - pharmacology Metals - chemistry Mice Mice, Inbred BALB C Microscopy, Electron, Transmission Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Optimization Particle size Pharmacokinetics Photon correlation spectroscopy Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polylactide-co-glycolide Polymers Porphyrins - chemistry Rats Rats, Wistar Reactive oxygen species Solvents Spectroscopy, Fourier Transform Infrared Statistical analysis Tissue Distribution X-Ray Diffraction
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