Association between Serum Lipid Parameters and Cognitive Performance in Older Adults
(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the...
Gespeichert in:
Veröffentlicht in: | Journal of clinical medicine 2021-11, Vol.10 (22), p.5405 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 22 |
container_start_page | 5405 |
container_title | Journal of clinical medicine |
container_volume | 10 |
creator | Lee, Jaeho Lee, Sohyae Min, Jin-young Min, Kyoung-bok |
description | (1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; p < 0.0001), HDL (r = 0.127; p < 0.0001), and LDL (r = 0.107; p = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; p = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; p < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; p = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment. |
doi_str_mv | 10.3390/jcm10225405 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8617666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2604019969</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-2ef59b057a7bac911fb3d6043088453b6cbbe3da5a762479cba31efbb637aee83</originalsourceid><addsrcrecordid>eNpdkU9LxDAQxYMoKurJLxDwIshq0mmT9iIsi_9gwQXXc0jSqWZpkzVpV_z2dlFEncsMzI_HezxCTjm7BKjY1cp2nGVZkbNihxxmTMoJgxJ2f90H5CSlFRunLPOMy31yAHkJTJTykCynKQXrdO-Cpwb7d0RPnzAOHZ27tavpQkfdYY8xUe1rOgsv3vVug3SBsQmx094idZ4-tjVGOq2Htk_HZK_RbcKT731Enm9vlrP7yfzx7mE2nU8slKKfZNgUlWGF1NJoW3HeGKgFy2FrtAAjrDEItS60FFkuK2s0cGyMESA1YglH5PpLdz2YDmuLvo-6VevoOh0_VNBO_f1496pewkaVgkshxChw_i0Qw9uAqVedSxbbVnsMQ1LZ6IbxqhLViJ79Q1dhiH6Mt6UyzoDDlrr4omwMKUVsfsxwpraFqV-FwScYBIfc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2602103139</pqid></control><display><type>article</type><title>Association between Serum Lipid Parameters and Cognitive Performance in Older Adults</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Lee, Jaeho ; Lee, Sohyae ; Min, Jin-young ; Min, Kyoung-bok</creator><creatorcontrib>Lee, Jaeho ; Lee, Sohyae ; Min, Jin-young ; Min, Kyoung-bok</creatorcontrib><description>(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; p < 0.0001), HDL (r = 0.127; p < 0.0001), and LDL (r = 0.107; p = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; p = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; p < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; p = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm10225405</identifier><identifier>PMID: 34830687</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Alzheimer's disease ; Blood pressure ; Body mass index ; Cardiovascular disease ; Cholesterol ; Clinical medicine ; Cognitive ability ; Dementia ; Diabetes ; Education ; Ethnicity ; Family income ; Health behavior ; High density lipoprotein ; Hispanic people ; Hypertension ; Lipids ; Older people ; Overweight ; Pain ; Population ; Questionnaires ; Smoking</subject><ispartof>Journal of clinical medicine, 2021-11, Vol.10 (22), p.5405</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-2ef59b057a7bac911fb3d6043088453b6cbbe3da5a762479cba31efbb637aee83</citedby><cites>FETCH-LOGICAL-c386t-2ef59b057a7bac911fb3d6043088453b6cbbe3da5a762479cba31efbb637aee83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617666/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8617666/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Lee, Jaeho</creatorcontrib><creatorcontrib>Lee, Sohyae</creatorcontrib><creatorcontrib>Min, Jin-young</creatorcontrib><creatorcontrib>Min, Kyoung-bok</creatorcontrib><title>Association between Serum Lipid Parameters and Cognitive Performance in Older Adults</title><title>Journal of clinical medicine</title><description>(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; p < 0.0001), HDL (r = 0.127; p < 0.0001), and LDL (r = 0.107; p = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; p = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; p < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; p = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment.</description><subject>Alzheimer's disease</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Clinical medicine</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Diabetes</subject><subject>Education</subject><subject>Ethnicity</subject><subject>Family income</subject><subject>Health behavior</subject><subject>High density lipoprotein</subject><subject>Hispanic people</subject><subject>Hypertension</subject><subject>Lipids</subject><subject>Older people</subject><subject>Overweight</subject><subject>Pain</subject><subject>Population</subject><subject>Questionnaires</subject><subject>Smoking</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU9LxDAQxYMoKurJLxDwIshq0mmT9iIsi_9gwQXXc0jSqWZpkzVpV_z2dlFEncsMzI_HezxCTjm7BKjY1cp2nGVZkbNihxxmTMoJgxJ2f90H5CSlFRunLPOMy31yAHkJTJTykCynKQXrdO-Cpwb7d0RPnzAOHZ27tavpQkfdYY8xUe1rOgsv3vVug3SBsQmx094idZ4-tjVGOq2Htk_HZK_RbcKT731Enm9vlrP7yfzx7mE2nU8slKKfZNgUlWGF1NJoW3HeGKgFy2FrtAAjrDEItS60FFkuK2s0cGyMESA1YglH5PpLdz2YDmuLvo-6VevoOh0_VNBO_f1496pewkaVgkshxChw_i0Qw9uAqVedSxbbVnsMQ1LZ6IbxqhLViJ79Q1dhiH6Mt6UyzoDDlrr4omwMKUVsfsxwpraFqV-FwScYBIfc</recordid><startdate>20211119</startdate><enddate>20211119</enddate><creator>Lee, Jaeho</creator><creator>Lee, Sohyae</creator><creator>Min, Jin-young</creator><creator>Min, Kyoung-bok</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211119</creationdate><title>Association between Serum Lipid Parameters and Cognitive Performance in Older Adults</title><author>Lee, Jaeho ; Lee, Sohyae ; Min, Jin-young ; Min, Kyoung-bok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2ef59b057a7bac911fb3d6043088453b6cbbe3da5a762479cba31efbb637aee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer's disease</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Clinical medicine</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Diabetes</topic><topic>Education</topic><topic>Ethnicity</topic><topic>Family income</topic><topic>Health behavior</topic><topic>High density lipoprotein</topic><topic>Hispanic people</topic><topic>Hypertension</topic><topic>Lipids</topic><topic>Older people</topic><topic>Overweight</topic><topic>Pain</topic><topic>Population</topic><topic>Questionnaires</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jaeho</creatorcontrib><creatorcontrib>Lee, Sohyae</creatorcontrib><creatorcontrib>Min, Jin-young</creatorcontrib><creatorcontrib>Min, Kyoung-bok</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jaeho</au><au>Lee, Sohyae</au><au>Min, Jin-young</au><au>Min, Kyoung-bok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Serum Lipid Parameters and Cognitive Performance in Older Adults</atitle><jtitle>Journal of clinical medicine</jtitle><date>2021-11-19</date><risdate>2021</risdate><volume>10</volume><issue>22</issue><spage>5405</spage><pages>5405-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>(1) Background: Previous studies have suggested the association between lipid profiles and cognitive function in older adults. However, they generated inconsistent results. We aim to determine the relationship between lipid profiles and cognitive performance in older adults. (2) Methods: We used the 2011–2014 National Health and Nutrition Examination Survey. This study included 2215 participants who were aged more than 60 years old and free of coronary heart disease or stroke. Lipid profiles included total cholesterol (TC), low density lipid cholesterol (LDL), high density lipid cholesterol (HDL), and triglyceride (TG). Cognitive function was assessed using the digit symbol substitution test (DSST). (3) Results: Positive correlations of DSST were observed with TC (r = 0.111; p < 0.0001), HDL (r = 0.127; p < 0.0001), and LDL (r = 0.107; p = 0.0005). However, there was no significant relationship between TG and DSST. A one-unit increase in HDL was associated with an increase in DSST score (beta coefficient: 0.036; p = 0.018); but the association was not significant for LDL, TG, and TC. In the categorical analysis, the high HDL group had a higher DSST score than the low HDL group (beta = 3.113; p < 0.0001) and the low TG group was more likely to show a lower DSST score than the high TC group (beta = −1.837; p = 0.0461). However, LDL and TC showed no statistically significant associations. Moreover, HDL was only associated with a 0.701 times increased risk of cognitive impairment (95% CI = 0.523–0.938) in the logistic regression analysis. (4) Conclusions: Higher blood concentrations of HDL levels were positively associated with DSST scores in older adults. We suggest that the high levels of HDL may be a protective factor against cognitive impairment.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34830687</pmid><doi>10.3390/jcm10225405</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2077-0383 |
ispartof | Journal of clinical medicine, 2021-11, Vol.10 (22), p.5405 |
issn | 2077-0383 2077-0383 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8617666 |
source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
subjects | Alzheimer's disease Blood pressure Body mass index Cardiovascular disease Cholesterol Clinical medicine Cognitive ability Dementia Diabetes Education Ethnicity Family income Health behavior High density lipoprotein Hispanic people Hypertension Lipids Older people Overweight Pain Population Questionnaires Smoking |
title | Association between Serum Lipid Parameters and Cognitive Performance in Older Adults |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T20%3A03%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20Serum%20Lipid%20Parameters%20and%20Cognitive%20Performance%20in%20Older%20Adults&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Lee,%20Jaeho&rft.date=2021-11-19&rft.volume=10&rft.issue=22&rft.spage=5405&rft.pages=5405-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm10225405&rft_dat=%3Cproquest_pubme%3E2604019969%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2602103139&rft_id=info:pmid/34830687&rfr_iscdi=true |