Angiotensin II biphasically regulates cell differentiation in human iPSC-derived kidney organoids

Human kidney organoid technology holds promise for novel kidney disease treatment strategies and utility in pharmacological and basic science. Given the crucial roles of the intrarenal renin-angiotensin system (RAS) and angiotensin II (ANG II) in the progression of kidney development and injury, we...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2021-11, Vol.321 (5), p.F559-F571
Hauptverfasser:	Yanofsky, Stacy M, Dugas, Courtney M, Katsurada, Akemi, Liu, Jiao, Saifudeen, Zubaida, El-Dahr, Samir S, Satou, Ryousuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Angiotensin II - pharmacology Cell differentiation Cell Differentiation - drug effects Cell Line Gene expression Gene Expression Regulation, Developmental Humans Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Kidney - cytology Kidney - drug effects Kidney - metabolism Kidney diseases Mesenchyme Organoids Organoids - cytology Organoids - drug effects Organoids - metabolism Pluripotency Proximal tubules Receptor, Angiotensin, Type 1 - agonists Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Receptor, Angiotensin, Type 2 - agonists Receptor, Angiotensin, Type 2 - genetics Receptor, Angiotensin, Type 2 - metabolism Renal tubules Renin Renin-Angiotensin System - drug effects Signal Transduction Stem cells Time Factors Ureter
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