Identification of an Immunogenic Medulloblastoma-Specific Fusion Involving EPC2 and GULP1

Medulloblastoma is the most common malignant brain tumor in children. Immunotherapy is yet to demonstrate dramatic results in medulloblastoma, one reason being the low rate of mutations creating new antigens in this entity. In tumors with low mutational burden, gene fusions may represent a source of...

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Veröffentlicht in:	Cancers 2021-11, Vol.13 (22), p.5838
Hauptverfasser:	Paret, Claudia, Lehmann, Nadine, Bender, Hannah, Sprang, Maximilian, Sommer, Clemens J., Cana, Denis, Seidmann, Larissa, Wingerter, Arthur, Neu, Marie A., El Malki, Khalifa, Alt, Francesca, Roth, Lea, Marini, Federico, Ottenhausen, Malte, Glaser, Martin, Knuf, Markus, Russo, Alexandra, Faber, Joerg
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Antigen (tumor-associated) Antigens Brain cancer Brain research Brain tumors Cancer therapies CD8 antigen Children Chromosome 2 Clinical trials Coding Cytotoxicity Fusion protein Genomes Histocompatibility antigen HLA Immunogenicity Immunotherapy Interferon Lymphocytes T Medical research Medulloblastoma Neoantigens Patients Pediatrics Peptides Polycomb group proteins Transcription Tumors
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