Updates on Immunotherapy and Immune Landscape in Renal Clear Cell Carcinoma

Several clinicopathological features of clear cell renal cell carcinomas (ccRCC) contribute to make an “atypical” cancer, including resistance to chemotherapy, sensitivity to anti-angiogenesis therapy and ICIs despite a low mutational burden, and CD8+ T cell infiltration being the predictor for poor...

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Veröffentlicht in:	Cancers 2021-11, Vol.13 (22), p.5856
Hauptverfasser:	Kim, Myung-Chul, Jin, Zeng, Kolb, Ryan, Borcherding, Nicholas, Chatzkel, Jonathan Alexander, Falzarano, Sara Moscovita, Zhang, Weizhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antigen presentation Biomarkers Cancer CD8 antigen Chemotherapy Clear cell-type renal cell carcinoma Clinical trials Cytokines Cytotoxicity Drug dosages FDA approval Immune checkpoint inhibitors Immunotherapy Infiltration Kinases Lymphocytes Lymphocytes T Macrophages Medical prognosis Metastases Metastasis Mutation Patients Review Reviews Tumor microenvironment Tumor-infiltrating lymphocytes Tumors Vascular endothelial growth factor
Online-Zugang:	Volltext
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