Influence of TP53 Mutation on Survival of Diffuse Large B-Cell Lymphoma in the CAR T-Cell Era

Refractory/relapsed diffuse large B-cell lymphoma (DLBCL) is associated with poor outcome. The clinical behavior and genetic landscape of DLBCL is heterogeneous and still not fully understood. TP53 mutations in DLBCL have been identified as markers of poor prognosis and are often associated with the...

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Veröffentlicht in:	Cancers 2021-11, Vol.13 (22), p.5592
Hauptverfasser:	Porpaczy, Edit, Wohlfarth, Philipp, Königsbrügge, Oliver, Rabitsch, Werner, Skrabs, Cathrin, Staber, Philipp, Worel, Nina, Müllauer, Leonhard, Simonitsch-Klupp, Ingrid, Kornauth, Christoph, Rohrbeck, Johannes, Jaeger, Ulrich, Schiefer, Ana-Iris
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies B-cell lymphoma Bcl-6 protein CD19 antigen Cell cycle Cell therapy Chemoresistance Chemotherapy Chimeric antigen receptors Cloning Cytotoxicity Drug resistance Genes Immune system Immunomodulation Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Medical innovations Medical prognosis Mutation Myc protein p53 Protein Patients Protein expression Risk factors Software Transplants & implants Tumor cells
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