Overexpression of miR-224-5p alleviates allergic rhinitis in mice via the TLR4/MyD88/NF-κB pathway

Inflammatory allergic reaction is the main cause of allergic rhinitis (AR). Previous studies indicated that miR-224-5p was downregulated in the nasal mucosa of patients with AR, while the function of miR-224-5p in AR remains unclear. To explore this issue, AR mouse model was established using ovalbu...

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Veröffentlicht in:	Experimental Animals 2021, Vol.70(4), pp.440-449
Hauptverfasser:	Wu, Jianhua, Wu, Lizhen, Zhang, Li, Xu, Huanhuan, Wang, Min, Wang, Lin, Chen, Jie, Sun, Kaiyue
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Allergic reactions Allergic rhinitis Hypersensitivity Immunoglobulin E Inflammasomes Inflammation inflammatory response miR-224-5p Mucosa MyD88 protein NF-κB protein Original Ovalbumin Reverse transcription Rhinitis Rubbing Sneezing Staining TLR4 protein TLR4/MyD88/NF-κB pathway Toll-like receptors
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