Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity
Objective This study aimed to examine whether total, regional, and organ fat predicts bone marrow adipose tissue (BMAT) fat content and to explore whether BMAT fat content differs by sex among Latino youth. Methods Latino youth (n = 86; age 13.6 [1.4] years, 62% male) with obesity (BMI percentile =...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2021-12, Vol.29 (12), p.2100-2107 |
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| creator | Vander Wyst, Kiley B. Hu, Houchun H. Peña, Armando Olson, Micah L. Bailey, Smita S. Shaibi, Gabriel Q. |
| description | Objective
This study aimed to examine whether total, regional, and organ fat predicts bone marrow adipose tissue (BMAT) fat content and to explore whether BMAT fat content differs by sex among Latino youth.
Methods
Latino youth (n = 86; age 13.6 [1.4] years, 62% male) with obesity (BMI percentile = 98.5% [1.2%]) underwent a dual‐energy x‐ray absorptiometry scan to assess body composition and a magnetic resonance imaging scan to determine abdominal adiposity, liver fat, and vertebral BMAT fat content in the thoracic (average of T8‐T12) and lumbar (average of L1‐L5) spine.
Results
Male youth exhibited significantly greater thoracic (male youth = 30.8% [1.4%] vs. female youth = 24.5% [2.1%], p = 0.027) and lumbar (male youth = 36.3% [1.5%] vs. female youth = 30.2% [2.2%], p = 0.038) BMAT fat content compared with female youth. Visceral adipose tissue was a significant predictor of thoracic (β = 0.434, t[86] = 3.016, p = 0.003) and lumbar (β = 0.389, t[86] = 2.677, p = 0.009) BMAT fat content, explaining 8.9% and 6.9% of the variance, respectively. Liver fat was a significant predictor of both thoracic (β = 0.487, t[86] = 4.334, p < 0.001) and lumbar (β = 0.436, t[86] = 3.793, p < 0.001) BMAT fat content, explaining 17.6% and 13.8% of the variance, respectively.
Conclusions
Male youth had significantly greater thoracic and lumbar BMAT fat content than female youth. Greater BMAT fat content is associated with greater liver fat and visceral adipose tissue among youth with obesity. Further investigation of the mechanistic underpinnings of BMAT may help to differentiate its metabolic and bone‐related functions. |
| doi_str_mv | 10.1002/oby.23279 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8612952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577465244</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4439-e92f514e6c92c003b92188b58e9d6a597778d354fce675e2930fd579d9b8b15a3</originalsourceid><addsrcrecordid>eNp1kc1qGzEYRUVpaRy3i75AEHSTLGzrZzSSNoEmpE3B4E0M7UpoZr5JZMaSI83U-O2jxKlJAllJSIfDvVyEvlEypYSwWah2U8aZ1B_QiGpOJpLrPx8Pd0WP0HFKK0KKkgj6GR3xQihGtB6h5UXwgNc2xrDFtnGbkAD3LqUBcB18D77HzuO57Z0PGQgdpDo_Jrx1_R3eRGicraCHhK1vcKgguX73BX1qbZfg6_M5RsufVzeX15P54tfvyx_zSV0UXE9As1bQAspas5oQXmlGlaqEAt2UVmgppWq4KNoaSimA5TptI6RudKUqKiwfo_O9dzNUa2geg0XbmU10udHOBOvM6x_v7sxt-GdUSZkWLAtOnwUx3A-QerN2uV_XWQ9hSIYJKYtSsBx3jL6_QVdhiD7XM6wkjBJBuMrU2Z6qY0gpQnsIQ4l5HMvksczTWJk9eZn-QP5fJwOzPbB1HezeN5nFxd-98gF1ip8v</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2602105038</pqid></control><display><type>article</type><title>Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity</title><source>MEDLINE</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Vander Wyst, Kiley B. ; Hu, Houchun H. ; Peña, Armando ; Olson, Micah L. ; Bailey, Smita S. ; Shaibi, Gabriel Q.</creator><creatorcontrib>Vander Wyst, Kiley B. ; Hu, Houchun H. ; Peña, Armando ; Olson, Micah L. ; Bailey, Smita S. ; Shaibi, Gabriel Q.</creatorcontrib><description>Objective
This study aimed to examine whether total, regional, and organ fat predicts bone marrow adipose tissue (BMAT) fat content and to explore whether BMAT fat content differs by sex among Latino youth.
Methods
Latino youth (n = 86; age 13.6 [1.4] years, 62% male) with obesity (BMI percentile = 98.5% [1.2%]) underwent a dual‐energy x‐ray absorptiometry scan to assess body composition and a magnetic resonance imaging scan to determine abdominal adiposity, liver fat, and vertebral BMAT fat content in the thoracic (average of T8‐T12) and lumbar (average of L1‐L5) spine.
Results
Male youth exhibited significantly greater thoracic (male youth = 30.8% [1.4%] vs. female youth = 24.5% [2.1%], p = 0.027) and lumbar (male youth = 36.3% [1.5%] vs. female youth = 30.2% [2.2%], p = 0.038) BMAT fat content compared with female youth. Visceral adipose tissue was a significant predictor of thoracic (β = 0.434, t[86] = 3.016, p = 0.003) and lumbar (β = 0.389, t[86] = 2.677, p = 0.009) BMAT fat content, explaining 8.9% and 6.9% of the variance, respectively. Liver fat was a significant predictor of both thoracic (β = 0.487, t[86] = 4.334, p < 0.001) and lumbar (β = 0.436, t[86] = 3.793, p < 0.001) BMAT fat content, explaining 17.6% and 13.8% of the variance, respectively.
Conclusions
Male youth had significantly greater thoracic and lumbar BMAT fat content than female youth. Greater BMAT fat content is associated with greater liver fat and visceral adipose tissue among youth with obesity. Further investigation of the mechanistic underpinnings of BMAT may help to differentiate its metabolic and bone‐related functions.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.23279</identifier><identifier>PMID: 34582099</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Abdomen ; Adipose Tissue - diagnostic imaging ; Adolescent ; Body composition ; Body fat ; Bone Density ; Bone marrow ; Bone Marrow - diagnostic imaging ; Children & youth ; Demographics ; Diabetes ; Female ; Gender differences ; Glucose ; Hispanic or Latino ; Humans ; Liver ; Magnetic resonance imaging ; Male ; Metabolism ; Obesity ; Obesity, Abdominal - diagnostic imaging ; Prediabetic State ; Teenagers ; Vertebrae ; Weight control</subject><ispartof>Obesity (Silver Spring, Md.), 2021-12, Vol.29 (12), p.2100-2107</ispartof><rights>2021 The Obesity Society</rights><rights>2021 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Dec 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4439-e92f514e6c92c003b92188b58e9d6a597778d354fce675e2930fd579d9b8b15a3</citedby><cites>FETCH-LOGICAL-c4439-e92f514e6c92c003b92188b58e9d6a597778d354fce675e2930fd579d9b8b15a3</cites><orcidid>0000-0002-6890-2903</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.23279$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.23279$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34582099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vander Wyst, Kiley B.</creatorcontrib><creatorcontrib>Hu, Houchun H.</creatorcontrib><creatorcontrib>Peña, Armando</creatorcontrib><creatorcontrib>Olson, Micah L.</creatorcontrib><creatorcontrib>Bailey, Smita S.</creatorcontrib><creatorcontrib>Shaibi, Gabriel Q.</creatorcontrib><title>Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
This study aimed to examine whether total, regional, and organ fat predicts bone marrow adipose tissue (BMAT) fat content and to explore whether BMAT fat content differs by sex among Latino youth.
Methods
Latino youth (n = 86; age 13.6 [1.4] years, 62% male) with obesity (BMI percentile = 98.5% [1.2%]) underwent a dual‐energy x‐ray absorptiometry scan to assess body composition and a magnetic resonance imaging scan to determine abdominal adiposity, liver fat, and vertebral BMAT fat content in the thoracic (average of T8‐T12) and lumbar (average of L1‐L5) spine.
Results
Male youth exhibited significantly greater thoracic (male youth = 30.8% [1.4%] vs. female youth = 24.5% [2.1%], p = 0.027) and lumbar (male youth = 36.3% [1.5%] vs. female youth = 30.2% [2.2%], p = 0.038) BMAT fat content compared with female youth. Visceral adipose tissue was a significant predictor of thoracic (β = 0.434, t[86] = 3.016, p = 0.003) and lumbar (β = 0.389, t[86] = 2.677, p = 0.009) BMAT fat content, explaining 8.9% and 6.9% of the variance, respectively. Liver fat was a significant predictor of both thoracic (β = 0.487, t[86] = 4.334, p < 0.001) and lumbar (β = 0.436, t[86] = 3.793, p < 0.001) BMAT fat content, explaining 17.6% and 13.8% of the variance, respectively.
Conclusions
Male youth had significantly greater thoracic and lumbar BMAT fat content than female youth. Greater BMAT fat content is associated with greater liver fat and visceral adipose tissue among youth with obesity. Further investigation of the mechanistic underpinnings of BMAT may help to differentiate its metabolic and bone‐related functions.</description><subject>Abdomen</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adolescent</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Bone Density</subject><subject>Bone marrow</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Children & youth</subject><subject>Demographics</subject><subject>Diabetes</subject><subject>Female</subject><subject>Gender differences</subject><subject>Glucose</subject><subject>Hispanic or Latino</subject><subject>Humans</subject><subject>Liver</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Obesity, Abdominal - diagnostic imaging</subject><subject>Prediabetic State</subject><subject>Teenagers</subject><subject>Vertebrae</subject><subject>Weight control</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1qGzEYRUVpaRy3i75AEHSTLGzrZzSSNoEmpE3B4E0M7UpoZr5JZMaSI83U-O2jxKlJAllJSIfDvVyEvlEypYSwWah2U8aZ1B_QiGpOJpLrPx8Pd0WP0HFKK0KKkgj6GR3xQihGtB6h5UXwgNc2xrDFtnGbkAD3LqUBcB18D77HzuO57Z0PGQgdpDo_Jrx1_R3eRGicraCHhK1vcKgguX73BX1qbZfg6_M5RsufVzeX15P54tfvyx_zSV0UXE9As1bQAspas5oQXmlGlaqEAt2UVmgppWq4KNoaSimA5TptI6RudKUqKiwfo_O9dzNUa2geg0XbmU10udHOBOvM6x_v7sxt-GdUSZkWLAtOnwUx3A-QerN2uV_XWQ9hSIYJKYtSsBx3jL6_QVdhiD7XM6wkjBJBuMrU2Z6qY0gpQnsIQ4l5HMvksczTWJk9eZn-QP5fJwOzPbB1HezeN5nFxd-98gF1ip8v</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Vander Wyst, Kiley B.</creator><creator>Hu, Houchun H.</creator><creator>Peña, Armando</creator><creator>Olson, Micah L.</creator><creator>Bailey, Smita S.</creator><creator>Shaibi, Gabriel Q.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6890-2903</orcidid></search><sort><creationdate>202112</creationdate><title>Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity</title><author>Vander Wyst, Kiley B. ; Hu, Houchun H. ; Peña, Armando ; Olson, Micah L. ; Bailey, Smita S. ; Shaibi, Gabriel Q.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4439-e92f514e6c92c003b92188b58e9d6a597778d354fce675e2930fd579d9b8b15a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdomen</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adolescent</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Bone Density</topic><topic>Bone marrow</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Children & youth</topic><topic>Demographics</topic><topic>Diabetes</topic><topic>Female</topic><topic>Gender differences</topic><topic>Glucose</topic><topic>Hispanic or Latino</topic><topic>Humans</topic><topic>Liver</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Obesity, Abdominal - diagnostic imaging</topic><topic>Prediabetic State</topic><topic>Teenagers</topic><topic>Vertebrae</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vander Wyst, Kiley B.</creatorcontrib><creatorcontrib>Hu, Houchun H.</creatorcontrib><creatorcontrib>Peña, Armando</creatorcontrib><creatorcontrib>Olson, Micah L.</creatorcontrib><creatorcontrib>Bailey, Smita S.</creatorcontrib><creatorcontrib>Shaibi, Gabriel Q.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vander Wyst, Kiley B.</au><au>Hu, Houchun H.</au><au>Peña, Armando</au><au>Olson, Micah L.</au><au>Bailey, Smita S.</au><au>Shaibi, Gabriel Q.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2021-12</date><risdate>2021</risdate><volume>29</volume><issue>12</issue><spage>2100</spage><epage>2107</epage><pages>2100-2107</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
This study aimed to examine whether total, regional, and organ fat predicts bone marrow adipose tissue (BMAT) fat content and to explore whether BMAT fat content differs by sex among Latino youth.
Methods
Latino youth (n = 86; age 13.6 [1.4] years, 62% male) with obesity (BMI percentile = 98.5% [1.2%]) underwent a dual‐energy x‐ray absorptiometry scan to assess body composition and a magnetic resonance imaging scan to determine abdominal adiposity, liver fat, and vertebral BMAT fat content in the thoracic (average of T8‐T12) and lumbar (average of L1‐L5) spine.
Results
Male youth exhibited significantly greater thoracic (male youth = 30.8% [1.4%] vs. female youth = 24.5% [2.1%], p = 0.027) and lumbar (male youth = 36.3% [1.5%] vs. female youth = 30.2% [2.2%], p = 0.038) BMAT fat content compared with female youth. Visceral adipose tissue was a significant predictor of thoracic (β = 0.434, t[86] = 3.016, p = 0.003) and lumbar (β = 0.389, t[86] = 2.677, p = 0.009) BMAT fat content, explaining 8.9% and 6.9% of the variance, respectively. Liver fat was a significant predictor of both thoracic (β = 0.487, t[86] = 4.334, p < 0.001) and lumbar (β = 0.436, t[86] = 3.793, p < 0.001) BMAT fat content, explaining 17.6% and 13.8% of the variance, respectively.
Conclusions
Male youth had significantly greater thoracic and lumbar BMAT fat content than female youth. Greater BMAT fat content is associated with greater liver fat and visceral adipose tissue among youth with obesity. Further investigation of the mechanistic underpinnings of BMAT may help to differentiate its metabolic and bone‐related functions.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>34582099</pmid><doi>10.1002/oby.23279</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6890-2903</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Abdomen Adipose Tissue - diagnostic imaging Adolescent Body composition Body fat Bone Density Bone marrow Bone Marrow - diagnostic imaging Children & youth Demographics Diabetes Female Gender differences Glucose Hispanic or Latino Humans Liver Magnetic resonance imaging Male Metabolism Obesity Obesity, Abdominal - diagnostic imaging Prediabetic State Teenagers Vertebrae Weight control |
| title | Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity |
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