Calcineurin regulates the stability and activity of estrogen receptor α

Estrogen receptor α (ER-α) mediates estrogen-dependent cancer progression and is expressed in most breast cancer cells. However, the molecular mechanisms underlying the regulation of the cellular abundance and activity of ER-α remain unclear. We here show that the protein phosphatase calcineurin reg...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-11, Vol.118 (44), p.1-12
Hauptverfasser:	Masaki, Takahiro, Habara, Makoto, Sato, Yuki, Goshima, Takahiro, Maeda, Keisuke, Hanaki, Shunsuke, Shimada, Midori
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Binding Biological Sciences Breast cancer Breast Neoplasms - metabolism Calcineurin Calcineurin - metabolism Calcineurin - physiology Cell Line, Tumor Chemical compounds Control stability Degradation Dephosphorylation Depletion Estradiol - pharmacology Estrogen Receptor alpha - drug effects Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Estrogens - metabolism Female Gene expression Gene Expression - genetics Gene Expression Regulation, Neoplastic - genetics Humans Kinases Molecular modelling Pharmacology Phosphorylation Proteasome Endopeptidase Complex - metabolism Protein phosphatase Protein Processing, Post-Translational - drug effects Proteins Rapamycin Receptors Receptors, Estrogen - drug effects Receptors, Estrogen - metabolism Sex hormones TOR protein Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitination - drug effects
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