A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia

Preeclampsia remains a major cause of maternal and neonatal morbidity and mortality. Biologic plausibility, compelling preliminary data, and a pilot clinical trial support the safety and utility of pravastatin for the prevention of preeclampsia. We previously reported the results of a phase I clinic...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2021-12, Vol.225 (6), p.666.e1-666.e15
Hauptverfasser:	Costantine, Maged M., West, Holly, Wisner, Katherine L., Caritis, Steve, Clark, Shannon, Venkataramanan, Raman, Stika, Catherine S., Rytting, Erik, Wang, Xiaoming, Ahmed, Mahmoud S., Welch, Elizabeth, Snodgrass, Wayne, Nanovskaya, Tatiana, Patrikeeva, Svetlana, Saade, George, Hankins, Gary, Pinheiro, Emily, O’Shea, Kelly, Cattan, Minaz, Mesches, Gabrielle, Ciolino, Jody, George, Alfred L., Fischer, Dawn, DeAngeles, Donna, Ren, Zhaoxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult angiogenic biomarkers Double-Blind Method Female high-risk pregnancy Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use investigational new drug maternal and neonatal morbidity myopathy pharmacokinetics Pilot Projects pilot randomized trial pravastatin Pravastatin - administration & dosage Pravastatin - pharmacokinetics Pravastatin - therapeutic use Pre-Eclampsia - prevention & control preeclampsia Pregnancy Pregnancy Trimester, Second Prenatal Care safety Treatment Outcome Young Adult
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