Camellia japonica Essential Oil Inhibits α-MSH-Induced Melanin Production and Tyrosinase Activity in B16F10 Melanoma Cells
Essential oils are aromatic oils extracted from the leaves, stems, peels, petals, and roots of aromatic plants grown in nature or grown in organic methods and have various medical effects as natural substances. The essential oil extracted from Camellia japonica seeds exhibits various functional prop...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2021-11, Vol.2021, p.1-8 |
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| creator | Ha, Si Young Jung, Ji Young Yang, Jae-Kyung |
| description | Essential oils are aromatic oils extracted from the leaves, stems, peels, petals, and roots of aromatic plants grown in nature or grown in organic methods and have various medical effects as natural substances. The essential oil extracted from Camellia japonica seeds exhibits various functional properties; however, its tyrosinase inhibitory activity has not been investigated extensively. This study is performed to investigate the chemical composition and tyrosinase inhibitory activity of Camellia japonica seed essential oil (CJS-EO). Hexamethylcyclotrisiloxane (42.36%) and octamethylcyclotetrasiloxane (23.28%) are the two primary components of CJS-EO, as identified via gas chromatography-mass spectrometry. The inhibitory activities of CJS-EO and positive control arbutin are further evaluated against mushroom tyrosinase. The results show that CJS-EO and arbutin inhibit tyrosinase activity. Moreover, CJS-EO significantly inhibits melanogenesis in the α-melanocyte-stimulating hormone-treated group, and a significant amount of melanin is suppressed. To ascertain the cause of the CJS-EO tyrosinase inhibitory effect and melanin reduction effect, genetic and protein analyses are performed. Based on our results, we tentatively conclude that CJS-EO can inhibit melanocytes from harmful factors such as tyrosinase-related protein. These results demonstrate that CJS-EO possesses potent antityrosinase activity and may be a good skin-whitening agent. |
| doi_str_mv | 10.1155/2021/6328767 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8610653</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2604012929</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-7cd4def09f52acc5e5848f09345ead655bfc3b9283d2c07608f032e3b9d7ec7e3</originalsourceid><addsrcrecordid>eNp9kd9KHDEUxkNpqX_aOx8g4E1Bp-bvZOZGsIvWBcVCLfQunE0ybpaZZDuZURafyhfxmcyyi1AvvErynV_OyZcPoQNKvlMq5QkjjJ6UnFWqVB_QLlWCFoJV1cfXvfq7g_ZSWhDCaqXUZ7TDRcWErNkuepxA59rWA17AMgZvAJ-n5MLgocU3vsXTMPczPyT8_FRc_74spsGOxll87VoIPuBffczC4GPAECy-XfUx-QDJ4bOs3vthhTP1g5YXlGwuxQ7wJM9MX9CnBtrkvm7XffTn4vx2cllc3fycTs6uCiOYHAplrLCuIXUjGRgjnaxElY9cSAe2lHLWGD6rWcUtM0SVJBc5c1myyhnl-D463fRdjrPOWZPd9dDqZe876Fc6gtf_V4Kf67t4r6uSklLy3ODbtkEf_40uDbrzyWQLEFwck2YlEYSymtUZPXyDLuLYh2xvTXFZU0pUpo43lMm_lXrXvD6GEr1OVa9T1dtUM360wec-WHjw79MvU4uhRA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2603591107</pqid></control><display><type>article</type><title>Camellia japonica Essential Oil Inhibits α-MSH-Induced Melanin Production and Tyrosinase Activity in B16F10 Melanoma Cells</title><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Ha, Si Young ; Jung, Ji Young ; Yang, Jae-Kyung</creator><contributor>Solano, Francisco ; Francisco Solano</contributor><creatorcontrib>Ha, Si Young ; Jung, Ji Young ; Yang, Jae-Kyung ; Solano, Francisco ; Francisco Solano</creatorcontrib><description>Essential oils are aromatic oils extracted from the leaves, stems, peels, petals, and roots of aromatic plants grown in nature or grown in organic methods and have various medical effects as natural substances. The essential oil extracted from Camellia japonica seeds exhibits various functional properties; however, its tyrosinase inhibitory activity has not been investigated extensively. This study is performed to investigate the chemical composition and tyrosinase inhibitory activity of Camellia japonica seed essential oil (CJS-EO). Hexamethylcyclotrisiloxane (42.36%) and octamethylcyclotetrasiloxane (23.28%) are the two primary components of CJS-EO, as identified via gas chromatography-mass spectrometry. The inhibitory activities of CJS-EO and positive control arbutin are further evaluated against mushroom tyrosinase. The results show that CJS-EO and arbutin inhibit tyrosinase activity. Moreover, CJS-EO significantly inhibits melanogenesis in the α-melanocyte-stimulating hormone-treated group, and a significant amount of melanin is suppressed. To ascertain the cause of the CJS-EO tyrosinase inhibitory effect and melanin reduction effect, genetic and protein analyses are performed. Based on our results, we tentatively conclude that CJS-EO can inhibit melanocytes from harmful factors such as tyrosinase-related protein. These results demonstrate that CJS-EO possesses potent antityrosinase activity and may be a good skin-whitening agent.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/6328767</identifier><identifier>PMID: 34824592</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Aromatherapy ; Camellia japonica ; Cell culture ; Chemical composition ; Essential oils ; Gas chromatography ; Genetic analysis ; Mass spectroscopy ; Medical research ; Melanin ; Melanocyte-stimulating hormone ; Melanocytes ; Melanoma ; Octamethylcyclotetrasiloxane ; Oils & fats ; Proteins ; Seeds ; Skin cancer</subject><ispartof>Evidence-based complementary and alternative medicine, 2021-11, Vol.2021, p.1-8</ispartof><rights>Copyright © 2021 Si Young Ha et al.</rights><rights>Copyright © 2021 Si Young Ha et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Si Young Ha et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-7cd4def09f52acc5e5848f09345ead655bfc3b9283d2c07608f032e3b9d7ec7e3</citedby><cites>FETCH-LOGICAL-c425t-7cd4def09f52acc5e5848f09345ead655bfc3b9283d2c07608f032e3b9d7ec7e3</cites><orcidid>0000-0002-9482-1584 ; 0000-0002-2832-5830</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610653/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610653/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids></links><search><contributor>Solano, Francisco</contributor><contributor>Francisco Solano</contributor><creatorcontrib>Ha, Si Young</creatorcontrib><creatorcontrib>Jung, Ji Young</creatorcontrib><creatorcontrib>Yang, Jae-Kyung</creatorcontrib><title>Camellia japonica Essential Oil Inhibits α-MSH-Induced Melanin Production and Tyrosinase Activity in B16F10 Melanoma Cells</title><title>Evidence-based complementary and alternative medicine</title><description>Essential oils are aromatic oils extracted from the leaves, stems, peels, petals, and roots of aromatic plants grown in nature or grown in organic methods and have various medical effects as natural substances. The essential oil extracted from Camellia japonica seeds exhibits various functional properties; however, its tyrosinase inhibitory activity has not been investigated extensively. This study is performed to investigate the chemical composition and tyrosinase inhibitory activity of Camellia japonica seed essential oil (CJS-EO). Hexamethylcyclotrisiloxane (42.36%) and octamethylcyclotetrasiloxane (23.28%) are the two primary components of CJS-EO, as identified via gas chromatography-mass spectrometry. The inhibitory activities of CJS-EO and positive control arbutin are further evaluated against mushroom tyrosinase. The results show that CJS-EO and arbutin inhibit tyrosinase activity. Moreover, CJS-EO significantly inhibits melanogenesis in the α-melanocyte-stimulating hormone-treated group, and a significant amount of melanin is suppressed. To ascertain the cause of the CJS-EO tyrosinase inhibitory effect and melanin reduction effect, genetic and protein analyses are performed. Based on our results, we tentatively conclude that CJS-EO can inhibit melanocytes from harmful factors such as tyrosinase-related protein. These results demonstrate that CJS-EO possesses potent antityrosinase activity and may be a good skin-whitening agent.</description><subject>Aromatherapy</subject><subject>Camellia japonica</subject><subject>Cell culture</subject><subject>Chemical composition</subject><subject>Essential oils</subject><subject>Gas chromatography</subject><subject>Genetic analysis</subject><subject>Mass spectroscopy</subject><subject>Medical research</subject><subject>Melanin</subject><subject>Melanocyte-stimulating hormone</subject><subject>Melanocytes</subject><subject>Melanoma</subject><subject>Octamethylcyclotetrasiloxane</subject><subject>Oils & fats</subject><subject>Proteins</subject><subject>Seeds</subject><subject>Skin cancer</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kd9KHDEUxkNpqX_aOx8g4E1Bp-bvZOZGsIvWBcVCLfQunE0ybpaZZDuZURafyhfxmcyyi1AvvErynV_OyZcPoQNKvlMq5QkjjJ6UnFWqVB_QLlWCFoJV1cfXvfq7g_ZSWhDCaqXUZ7TDRcWErNkuepxA59rWA17AMgZvAJ-n5MLgocU3vsXTMPczPyT8_FRc_74spsGOxll87VoIPuBffczC4GPAECy-XfUx-QDJ4bOs3vthhTP1g5YXlGwuxQ7wJM9MX9CnBtrkvm7XffTn4vx2cllc3fycTs6uCiOYHAplrLCuIXUjGRgjnaxElY9cSAe2lHLWGD6rWcUtM0SVJBc5c1myyhnl-D463fRdjrPOWZPd9dDqZe876Fc6gtf_V4Kf67t4r6uSklLy3ODbtkEf_40uDbrzyWQLEFwck2YlEYSymtUZPXyDLuLYh2xvTXFZU0pUpo43lMm_lXrXvD6GEr1OVa9T1dtUM360wec-WHjw79MvU4uhRA</recordid><startdate>20211116</startdate><enddate>20211116</enddate><creator>Ha, Si Young</creator><creator>Jung, Ji Young</creator><creator>Yang, Jae-Kyung</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9482-1584</orcidid><orcidid>https://orcid.org/0000-0002-2832-5830</orcidid></search><sort><creationdate>20211116</creationdate><title>Camellia japonica Essential Oil Inhibits α-MSH-Induced Melanin Production and Tyrosinase Activity in B16F10 Melanoma Cells</title><author>Ha, Si Young ; Jung, Ji Young ; Yang, Jae-Kyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-7cd4def09f52acc5e5848f09345ead655bfc3b9283d2c07608f032e3b9d7ec7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aromatherapy</topic><topic>Camellia japonica</topic><topic>Cell culture</topic><topic>Chemical composition</topic><topic>Essential oils</topic><topic>Gas chromatography</topic><topic>Genetic analysis</topic><topic>Mass spectroscopy</topic><topic>Medical research</topic><topic>Melanin</topic><topic>Melanocyte-stimulating hormone</topic><topic>Melanocytes</topic><topic>Melanoma</topic><topic>Octamethylcyclotetrasiloxane</topic><topic>Oils & fats</topic><topic>Proteins</topic><topic>Seeds</topic><topic>Skin cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ha, Si Young</creatorcontrib><creatorcontrib>Jung, Ji Young</creatorcontrib><creatorcontrib>Yang, Jae-Kyung</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ha, Si Young</au><au>Jung, Ji Young</au><au>Yang, Jae-Kyung</au><au>Solano, Francisco</au><au>Francisco Solano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Camellia japonica Essential Oil Inhibits α-MSH-Induced Melanin Production and Tyrosinase Activity in B16F10 Melanoma Cells</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2021-11-16</date><risdate>2021</risdate><volume>2021</volume><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Essential oils are aromatic oils extracted from the leaves, stems, peels, petals, and roots of aromatic plants grown in nature or grown in organic methods and have various medical effects as natural substances. The essential oil extracted from Camellia japonica seeds exhibits various functional properties; however, its tyrosinase inhibitory activity has not been investigated extensively. This study is performed to investigate the chemical composition and tyrosinase inhibitory activity of Camellia japonica seed essential oil (CJS-EO). Hexamethylcyclotrisiloxane (42.36%) and octamethylcyclotetrasiloxane (23.28%) are the two primary components of CJS-EO, as identified via gas chromatography-mass spectrometry. The inhibitory activities of CJS-EO and positive control arbutin are further evaluated against mushroom tyrosinase. The results show that CJS-EO and arbutin inhibit tyrosinase activity. Moreover, CJS-EO significantly inhibits melanogenesis in the α-melanocyte-stimulating hormone-treated group, and a significant amount of melanin is suppressed. To ascertain the cause of the CJS-EO tyrosinase inhibitory effect and melanin reduction effect, genetic and protein analyses are performed. Based on our results, we tentatively conclude that CJS-EO can inhibit melanocytes from harmful factors such as tyrosinase-related protein. These results demonstrate that CJS-EO possesses potent antityrosinase activity and may be a good skin-whitening agent.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>34824592</pmid><doi>10.1155/2021/6328767</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9482-1584</orcidid><orcidid>https://orcid.org/0000-0002-2832-5830</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aromatherapy Camellia japonica Cell culture Chemical composition Essential oils Gas chromatography Genetic analysis Mass spectroscopy Medical research Melanin Melanocyte-stimulating hormone Melanocytes Melanoma Octamethylcyclotetrasiloxane Oils & fats Proteins Seeds Skin cancer |
| title | Camellia japonica Essential Oil Inhibits α-MSH-Induced Melanin Production and Tyrosinase Activity in B16F10 Melanoma Cells |
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