NTCP Oligomerization Occurs Downstream of the NTCP-EGFR Interaction during Hepatitis B Virus Internalization

Sodium taurocholate cotransporting polypeptide (NTCP) is a receptor that is essential for hepatitis B virus (HBV) entry into the host cell. A number of HBV entry inhibitors targeting NTCP have been reported to date; these inhibitors have facilitated a mechanistic analysis of the viral entry process....

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Veröffentlicht in:	Journal of virology 2021-11, Vol.95 (24), p.e0093821
Hauptverfasser:	Fukano, Kento, Oshima, Mizuki, Tsukuda, Senko, Aizaki, Hideki, Ohki, Mio, Park, Sam-Yong, Wakita, Takaji, Wakae, Kousho, Watashi, Koichi, Muramatsu, Masamichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport ErbB Receptors - genetics ErbB Receptors - metabolism Hep G2 Cells Hepatitis B virus - physiology Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - virology Humans Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism Protein Multimerization Receptors, Virus - metabolism Symporters - genetics Symporters - metabolism Troglitazone - pharmacology Virology Virus Attachment - drug effects Virus Internalization - drug effects Virus-Cell Interactions
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