Evolution of Antibodies to Native Trimeric Envelope and Their Fc-Dependent Functions in Untreated and Treated Primary HIV Infection

People living with HIV (PLWH) develop both anti-envelope-specific antibodies, which bind the closed trimeric HIV envelope present on infected cells, and anti-gp120-specific antibodies, which bind gp120 monomers shed by infected cells and taken up by CD4 on uninfected bystander cells. Both antibodies...

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Veröffentlicht in:	Journal of virology 2021-11, Vol.95 (24), p.e0162521-e0162521
Hauptverfasser:	Nagel, Lauren, Kant, Sanket, Leeks, Christopher, Routy, Jean-Pierre, Tremblay, Cécile, Thomas, Réjean, Szabo, Jason, Côté, Pierre, Trottier, Benoit, LeBlanc, Roger, Rouleau, Danielle, Dupuy, Franck P, Bernard, Nicole F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing - immunology Antibody-Dependent Cell Cytotoxicity - immunology Cell Line HIV Antibodies - immunology HIV Infections - immunology HIV-1 - immunology Humans Immunoglobulin G - immunology Immunology Pathogenesis and Immunity Phagocytosis - immunology Receptors, Fc - immunology Receptors, Fc - metabolism Trogocytosis - immunology Viral Load
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