The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial
Purpose The understanding of the role of plasma antioxidant levels in male fertility in the USA is limited. In a secondary analysis of the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial, we sought to determine whether serum levels of vitamin E (α-tocopherol), zinc, and seleniu...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2021-11, Vol.38 (11), p.3005-3013 |
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| creator | Knudtson, Jennifer F. Sun, Fangbai Coward, R. Matthew Hansen, Karl R. Barnhart, Kurt T. Smith, James Legro, Richard S. Diamond, Michael P. Krawetz, Stephen A. Zhang, Heping Usadi, Rebecca Baker, Valerie L. Santoro, Nanette Steiner, Anne Z. |
| description | Purpose
The understanding of the role of plasma antioxidant levels in male fertility in the USA is limited. In a secondary analysis of the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial, we sought to determine whether serum levels of vitamin E (α-tocopherol), zinc, and selenium were correlated with semen parameters and couple fertility outcomes.
Methods
This study is a secondary analysis of the MOXI clinical trial. The primary endpoints in this secondary analysis include semen parameters, and DNA fragmentation and clinical outcomes including pregnancy and live birth. Analyses were completed using Wilcoxon’s rank-sum test and linear regression models.
Results
At baseline, the analysis included plasma labs for vitamin E (
n
= 131), selenium (
n
= 124), and zinc (
n
= 128). All baseline plasma values were in the normal ranges. There was no association between selenium, zinc, or vitamin E levels and semen parameters or DNA fragmentation. Baseline antioxidant levels in the male partners did not predict pregnancy or live birth among all couples. Among those randomized to placebo, baseline male antioxidant levels did not differ between those couples with live birth and those that did not conceive or have a live birth.
Conclusions
Among men attending fertility centers in the USA, who have sufficient plasma antioxidant levels of zinc, selenium, or vitamin E, no association was observed between vitamins and semen parameters or clinical outcomes in couples with male infertility. Higher levels of antioxidants among men with circulating antioxidants in the normal range do not appear to confer benefit on semen parameters or male fertility. |
| doi_str_mv | 10.1007/s10815-021-02301-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8609082</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2600521937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-b90f366efebaba21fff7494f957eb72a309ad0321181bc06920b3d2d72ebc6913</originalsourceid><addsrcrecordid>eNp9kV1vFCEUhonR2Hb1D3hhSLypiaMHGOajFyZN48cmbXpTE-8IM3Po0jCwAttYf0N_tKxbW_XCC3Lg8JyXc3gJecHgLQNo3yUGHZMVcFaWAFbxR2SfyVZUrRDwuOxBdhXUTbdHDlK6AoC-4-Ip2RN1LaWEdp_cXqyQRnQ62-DTyq5pMHTtdJo11b4kv9upROrwGl2iOdCEM3q61lHPmDGmI5qLxJl2mN7Q44eSctJ-oktvMGbrbL6hh2fnX5evaSz5MNsfONHRWW9H7WiOVrtn5InRLuHzu7ggXz5-uDj5XJ2ef1qeHJ9WY93WuRp6MKJp0OCgB82ZMaat-9r0ssWh5VpArycQnLGODSM0PYdBTHxqOQ5j0zOxIO93uuvNMOM0os9RO7WOdtbxRgVt1d833q7UZbhWXQM9lC9ckMM7gRi-bTBlNds0onPaY9gkxWXTcCm6ri3oq3_Qq7CJvoyneAMgOevFluI7aowhpYjmvhkGamu22pmtitnql9lq28XLP8e4L_ntbgHEDkjlyl9ifHj7P7I_Aehbt3Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2600521937</pqid></control><display><type>article</type><title>The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial</title><source>MEDLINE</source><source>Springer Journals</source><source>Free E-Journal (出版社公開部分のみ）</source><source>PubMed</source><creator>Knudtson, Jennifer F. ; Sun, Fangbai ; Coward, R. Matthew ; Hansen, Karl R. ; Barnhart, Kurt T. ; Smith, James ; Legro, Richard S. ; Diamond, Michael P. ; Krawetz, Stephen A. ; Zhang, Heping ; Usadi, Rebecca ; Baker, Valerie L. ; Santoro, Nanette ; Steiner, Anne Z.</creator><creatorcontrib>Knudtson, Jennifer F. ; Sun, Fangbai ; Coward, R. Matthew ; Hansen, Karl R. ; Barnhart, Kurt T. ; Smith, James ; Legro, Richard S. ; Diamond, Michael P. ; Krawetz, Stephen A. ; Zhang, Heping ; Usadi, Rebecca ; Baker, Valerie L. ; Santoro, Nanette ; Steiner, Anne Z.</creatorcontrib><description>Purpose
The understanding of the role of plasma antioxidant levels in male fertility in the USA is limited. In a secondary analysis of the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial, we sought to determine whether serum levels of vitamin E (α-tocopherol), zinc, and selenium were correlated with semen parameters and couple fertility outcomes.
Methods
This study is a secondary analysis of the MOXI clinical trial. The primary endpoints in this secondary analysis include semen parameters, and DNA fragmentation and clinical outcomes including pregnancy and live birth. Analyses were completed using Wilcoxon’s rank-sum test and linear regression models.
Results
At baseline, the analysis included plasma labs for vitamin E (
n
= 131), selenium (
n
= 124), and zinc (
n
= 128). All baseline plasma values were in the normal ranges. There was no association between selenium, zinc, or vitamin E levels and semen parameters or DNA fragmentation. Baseline antioxidant levels in the male partners did not predict pregnancy or live birth among all couples. Among those randomized to placebo, baseline male antioxidant levels did not differ between those couples with live birth and those that did not conceive or have a live birth.
Conclusions
Among men attending fertility centers in the USA, who have sufficient plasma antioxidant levels of zinc, selenium, or vitamin E, no association was observed between vitamins and semen parameters or clinical outcomes in couples with male infertility. Higher levels of antioxidants among men with circulating antioxidants in the normal range do not appear to confer benefit on semen parameters or male fertility.</description><identifier>ISSN: 1058-0468</identifier><identifier>ISSN: 1573-7330</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-021-02301-2</identifier><identifier>PMID: 34455507</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abortion, Spontaneous - epidemiology ; Adolescent ; Adult ; Antioxidants ; Antioxidants - analysis ; Clinical outcomes ; Clinical trials ; Couples ; Deoxyribonucleic acid ; DNA ; DNA fragmentation ; Female ; Fertility ; Fertilization in Vitro - methods ; Gynecology ; Human Genetics ; Humans ; Infertility ; Infertility, Male - blood ; Infertility, Male - therapy ; Live Birth - epidemiology ; Male ; Males ; Medicine ; Medicine & Public Health ; Oxidative Stress ; Plasma ; Pregnancy ; Pregnancy Rate ; Regression analysis ; Reproductive Medicine ; Reproductive Physiology and Disease ; Selenium ; Semen ; Semen - metabolism ; Semen Analysis ; Serum levels ; United States ; Vitamin E ; Vitamins ; Vitamins - blood ; Young Adult ; Zinc</subject><ispartof>Journal of assisted reproduction and genetics, 2021-11, Vol.38 (11), p.3005-3013</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b90f366efebaba21fff7494f957eb72a309ad0321181bc06920b3d2d72ebc6913</citedby><cites>FETCH-LOGICAL-c474t-b90f366efebaba21fff7494f957eb72a309ad0321181bc06920b3d2d72ebc6913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609082/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609082/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34455507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knudtson, Jennifer F.</creatorcontrib><creatorcontrib>Sun, Fangbai</creatorcontrib><creatorcontrib>Coward, R. Matthew</creatorcontrib><creatorcontrib>Hansen, Karl R.</creatorcontrib><creatorcontrib>Barnhart, Kurt T.</creatorcontrib><creatorcontrib>Smith, James</creatorcontrib><creatorcontrib>Legro, Richard S.</creatorcontrib><creatorcontrib>Diamond, Michael P.</creatorcontrib><creatorcontrib>Krawetz, Stephen A.</creatorcontrib><creatorcontrib>Zhang, Heping</creatorcontrib><creatorcontrib>Usadi, Rebecca</creatorcontrib><creatorcontrib>Baker, Valerie L.</creatorcontrib><creatorcontrib>Santoro, Nanette</creatorcontrib><creatorcontrib>Steiner, Anne Z.</creatorcontrib><title>The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
The understanding of the role of plasma antioxidant levels in male fertility in the USA is limited. In a secondary analysis of the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial, we sought to determine whether serum levels of vitamin E (α-tocopherol), zinc, and selenium were correlated with semen parameters and couple fertility outcomes.
Methods
This study is a secondary analysis of the MOXI clinical trial. The primary endpoints in this secondary analysis include semen parameters, and DNA fragmentation and clinical outcomes including pregnancy and live birth. Analyses were completed using Wilcoxon’s rank-sum test and linear regression models.
Results
At baseline, the analysis included plasma labs for vitamin E (
n
= 131), selenium (
n
= 124), and zinc (
n
= 128). All baseline plasma values were in the normal ranges. There was no association between selenium, zinc, or vitamin E levels and semen parameters or DNA fragmentation. Baseline antioxidant levels in the male partners did not predict pregnancy or live birth among all couples. Among those randomized to placebo, baseline male antioxidant levels did not differ between those couples with live birth and those that did not conceive or have a live birth.
Conclusions
Among men attending fertility centers in the USA, who have sufficient plasma antioxidant levels of zinc, selenium, or vitamin E, no association was observed between vitamins and semen parameters or clinical outcomes in couples with male infertility. Higher levels of antioxidants among men with circulating antioxidants in the normal range do not appear to confer benefit on semen parameters or male fertility.</description><subject>Abortion, Spontaneous - epidemiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - analysis</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Couples</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA fragmentation</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertilization in Vitro - methods</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Infertility</subject><subject>Infertility, Male - blood</subject><subject>Infertility, Male - therapy</subject><subject>Live Birth - epidemiology</subject><subject>Male</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oxidative Stress</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Regression analysis</subject><subject>Reproductive Medicine</subject><subject>Reproductive Physiology and Disease</subject><subject>Selenium</subject><subject>Semen</subject><subject>Semen - metabolism</subject><subject>Semen Analysis</subject><subject>Serum levels</subject><subject>United States</subject><subject>Vitamin E</subject><subject>Vitamins</subject><subject>Vitamins - blood</subject><subject>Young Adult</subject><subject>Zinc</subject><issn>1058-0468</issn><issn>1573-7330</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kV1vFCEUhonR2Hb1D3hhSLypiaMHGOajFyZN48cmbXpTE-8IM3Po0jCwAttYf0N_tKxbW_XCC3Lg8JyXc3gJecHgLQNo3yUGHZMVcFaWAFbxR2SfyVZUrRDwuOxBdhXUTbdHDlK6AoC-4-Ip2RN1LaWEdp_cXqyQRnQ62-DTyq5pMHTtdJo11b4kv9upROrwGl2iOdCEM3q61lHPmDGmI5qLxJl2mN7Q44eSctJ-oktvMGbrbL6hh2fnX5evaSz5MNsfONHRWW9H7WiOVrtn5InRLuHzu7ggXz5-uDj5XJ2ef1qeHJ9WY93WuRp6MKJp0OCgB82ZMaat-9r0ssWh5VpArycQnLGODSM0PYdBTHxqOQ5j0zOxIO93uuvNMOM0os9RO7WOdtbxRgVt1d833q7UZbhWXQM9lC9ckMM7gRi-bTBlNds0onPaY9gkxWXTcCm6ri3oq3_Qq7CJvoyneAMgOevFluI7aowhpYjmvhkGamu22pmtitnql9lq28XLP8e4L_ntbgHEDkjlyl9ifHj7P7I_Aehbt3Y</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Knudtson, Jennifer F.</creator><creator>Sun, Fangbai</creator><creator>Coward, R. Matthew</creator><creator>Hansen, Karl R.</creator><creator>Barnhart, Kurt T.</creator><creator>Smith, James</creator><creator>Legro, Richard S.</creator><creator>Diamond, Michael P.</creator><creator>Krawetz, Stephen A.</creator><creator>Zhang, Heping</creator><creator>Usadi, Rebecca</creator><creator>Baker, Valerie L.</creator><creator>Santoro, Nanette</creator><creator>Steiner, Anne Z.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211101</creationdate><title>The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial</title><author>Knudtson, Jennifer F. ; Sun, Fangbai ; Coward, R. Matthew ; Hansen, Karl R. ; Barnhart, Kurt T. ; Smith, James ; Legro, Richard S. ; Diamond, Michael P. ; Krawetz, Stephen A. ; Zhang, Heping ; Usadi, Rebecca ; Baker, Valerie L. ; Santoro, Nanette ; Steiner, Anne Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b90f366efebaba21fff7494f957eb72a309ad0321181bc06920b3d2d72ebc6913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abortion, Spontaneous - epidemiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - analysis</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Couples</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA fragmentation</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertilization in Vitro - methods</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Infertility</topic><topic>Infertility, Male - blood</topic><topic>Infertility, Male - therapy</topic><topic>Live Birth - epidemiology</topic><topic>Male</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oxidative Stress</topic><topic>Plasma</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Regression analysis</topic><topic>Reproductive Medicine</topic><topic>Reproductive Physiology and Disease</topic><topic>Selenium</topic><topic>Semen</topic><topic>Semen - metabolism</topic><topic>Semen Analysis</topic><topic>Serum levels</topic><topic>United States</topic><topic>Vitamin E</topic><topic>Vitamins</topic><topic>Vitamins - blood</topic><topic>Young Adult</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knudtson, Jennifer F.</creatorcontrib><creatorcontrib>Sun, Fangbai</creatorcontrib><creatorcontrib>Coward, R. Matthew</creatorcontrib><creatorcontrib>Hansen, Karl R.</creatorcontrib><creatorcontrib>Barnhart, Kurt T.</creatorcontrib><creatorcontrib>Smith, James</creatorcontrib><creatorcontrib>Legro, Richard S.</creatorcontrib><creatorcontrib>Diamond, Michael P.</creatorcontrib><creatorcontrib>Krawetz, Stephen A.</creatorcontrib><creatorcontrib>Zhang, Heping</creatorcontrib><creatorcontrib>Usadi, Rebecca</creatorcontrib><creatorcontrib>Baker, Valerie L.</creatorcontrib><creatorcontrib>Santoro, Nanette</creatorcontrib><creatorcontrib>Steiner, Anne Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knudtson, Jennifer F.</au><au>Sun, Fangbai</au><au>Coward, R. Matthew</au><au>Hansen, Karl R.</au><au>Barnhart, Kurt T.</au><au>Smith, James</au><au>Legro, Richard S.</au><au>Diamond, Michael P.</au><au>Krawetz, Stephen A.</au><au>Zhang, Heping</au><au>Usadi, Rebecca</au><au>Baker, Valerie L.</au><au>Santoro, Nanette</au><au>Steiner, Anne Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>38</volume><issue>11</issue><spage>3005</spage><epage>3013</epage><pages>3005-3013</pages><issn>1058-0468</issn><issn>1573-7330</issn><eissn>1573-7330</eissn><abstract>Purpose
The understanding of the role of plasma antioxidant levels in male fertility in the USA is limited. In a secondary analysis of the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial, we sought to determine whether serum levels of vitamin E (α-tocopherol), zinc, and selenium were correlated with semen parameters and couple fertility outcomes.
Methods
This study is a secondary analysis of the MOXI clinical trial. The primary endpoints in this secondary analysis include semen parameters, and DNA fragmentation and clinical outcomes including pregnancy and live birth. Analyses were completed using Wilcoxon’s rank-sum test and linear regression models.
Results
At baseline, the analysis included plasma labs for vitamin E (
n
= 131), selenium (
n
= 124), and zinc (
n
= 128). All baseline plasma values were in the normal ranges. There was no association between selenium, zinc, or vitamin E levels and semen parameters or DNA fragmentation. Baseline antioxidant levels in the male partners did not predict pregnancy or live birth among all couples. Among those randomized to placebo, baseline male antioxidant levels did not differ between those couples with live birth and those that did not conceive or have a live birth.
Conclusions
Among men attending fertility centers in the USA, who have sufficient plasma antioxidant levels of zinc, selenium, or vitamin E, no association was observed between vitamins and semen parameters or clinical outcomes in couples with male infertility. Higher levels of antioxidants among men with circulating antioxidants in the normal range do not appear to confer benefit on semen parameters or male fertility.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34455507</pmid><doi>10.1007/s10815-021-02301-2</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2021-11, Vol.38 (11), p.3005-3013 |
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| language | eng |
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| source | MEDLINE; Springer Journals; Free E-Journal (出版社公開部分のみ）; PubMed |
| subjects | Abortion, Spontaneous - epidemiology Adolescent Adult Antioxidants Antioxidants - analysis Clinical outcomes Clinical trials Couples Deoxyribonucleic acid DNA DNA fragmentation Female Fertility Fertilization in Vitro - methods Gynecology Human Genetics Humans Infertility Infertility, Male - blood Infertility, Male - therapy Live Birth - epidemiology Male Males Medicine Medicine & Public Health Oxidative Stress Plasma Pregnancy Pregnancy Rate Regression analysis Reproductive Medicine Reproductive Physiology and Disease Selenium Semen Semen - metabolism Semen Analysis Serum levels United States Vitamin E Vitamins Vitamins - blood Young Adult Zinc |
| title | The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial |
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