Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq

Hematopoiesis is hierarchical, and it has been postulated that acute myeloid leukemia (AML) is organized similarly with leukemia stem cells (LSCs) residing at the apex. Limited cells acquired by fluorescence activated cell sorting in tandem with targeted amplicon-based sequencing (LC-FACSeq) enables...

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Veröffentlicht in:	Leukemia 2021-12, Vol.35 (12), p.3406-3420
Hauptverfasser:	Saygin, Caner, Hu, Eileen, Zhang, Pu, Sher, Steven, Lozanski, Arletta, Doong, Tzyy-Jye, Nicolet, Deedra, Orwick, Shelley, Labanowska, Jadwiga, Skinner, Jordan N., Cempre, Casey, Kauffman, Tierney, Goettl, Virginia M., Heerema, Nyla A., Abruzzo, Lynne, Miller, Cecelia, Lapalombella, Rosa, Behbehani, Gregory, Mims, Alice S., Larkin, Karilyn, Grieselhuber, Nicole, Walker, Alison, Bhatnagar, Bhavana, Bloomfield, Clara D., Byrd, John C., Lozanski, Gerard, Blachly, James S.
Format:	Artikel
Sprache:	eng
Schlagworte:	45/100 45/23 631/208/68 692/699/1541/1990/283/1897 Acute myeloid leukemia Adult Aged Aged, 80 and over Biological evolution Biomarkers, Tumor - genetics Cancer Research Clonal Evolution Compartments Critical Care Medicine DNA methylation DNA sequencing Female Flow Cytometry Fluorescence Follow-Up Studies Gene amplification Genomic analysis Genomics - methods Health aspects Hematology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Heterogeneity Humans Immunophenotyping Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Male Medicine Medicine & Public Health Methods Middle Aged Mutation Myeloid leukemia Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nucleotide sequencing Oncology p53 Protein Physiological aspects Prognosis Remission Signal transduction Stem cells Subpopulations Transcription factors Young Adult
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