Presence or absence of microbiome modulates the response of mice organism to administered drug nabumetone

The gut microbiota provides a wide range of beneficial functions for the host, and has an immense effect on the host's health status. The presence of microbiome in the gut may often influence the effect of an orally administered drug. Molecular mechanisms of this process are however mostly uncl...

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Veröffentlicht in:	Physiological research 2020, Vol.69 (Suppl 4), p.S583-594
Hauptverfasser:	Jourová, L, Lišková, B, Lněničková, K, Zemanová, N, Anzenbacher, P, Hermanová, P, Hudcovic, T, Kozáková, H, Anzenbacherová, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation, Metabolic Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - metabolism Antibodies Bacteria - metabolism Bioavailability CYP1A protein Cytochrome Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Digestive system Drug metabolism Drugs Dysbiosis Enzymes Experiments Gastrointestinal Microbiome Gastrointestinal tract Intestinal microflora Intestine, Small - drug effects Intestine, Small - enzymology Intestine, Small - microbiology Liver Liver - drug effects Liver - enzymology Metabolism Metabolites Mice, Inbred BALB C Microbiomes Microbiota Molecular modelling Nabumetone - administration & dosage Nabumetone - metabolism Oral administration Pathogens Small intestine Specific pathogen free Transcription Factors - genetics Transcription Factors - metabolism
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