Short-term effects of nicotine on orthodontically induced root resorption in rats
To investigate the effect of nicotine exposure on root resorption in an in vivo rat model of orthodontic tooth movement (OTM), and its association with odontoclastogenesis and receptor activator of nuclear factor-kappa B ligand (RANKL) expression. Forty-eight 10-week-old male Wistar rats were divide...
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| Veröffentlicht in: | The Angle orthodontist 2016-03, Vol.86 (2), p.199-205 |
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| creator | Li, Jing Wang, Xuxia Li, Na Zhenga, Dehua Su, Yuran Zhang, Jun |
| description | To investigate the effect of nicotine exposure on root resorption in an in vivo rat model of orthodontic tooth movement (OTM), and its association with odontoclastogenesis and receptor activator of nuclear factor-kappa B ligand (RANKL) expression.
Forty-eight 10-week-old male Wistar rats were divided into three groups. The negative control group was untreated. The left maxillary first molars in the nicotine-treated group and the positive control group received OTM with an initial force of 0.6 N in the mesial direction. Also, the nicotine-treated group received intraperitoneal injection of nicotine at 7 mg/kg per day. After 21 days, the rats were humanely killed. Eight rats from each group were randomly chosen for crater volume analysis by micro-computed tomography. For the remaining eight rats in each group, specimen slices were generated for histologic examination to determine the odontoclast number and the mean optical density value of RANKL.
The resorption volumes in the nicotine-treated group were significantly larger than those in the control groups. Also, the nicotine-treated group displayed significantly higher number of odontoclasts and elevated RANKL expression compared to the control groups.
In an in vivo rat model, nicotine exposure promotes odontoclastogenesis and RANKL expression, evoking aggravated root resorption during OTM. |
| doi_str_mv | 10.2319/101014-727.1 |
| format | Article |
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Forty-eight 10-week-old male Wistar rats were divided into three groups. The negative control group was untreated. The left maxillary first molars in the nicotine-treated group and the positive control group received OTM with an initial force of 0.6 N in the mesial direction. Also, the nicotine-treated group received intraperitoneal injection of nicotine at 7 mg/kg per day. After 21 days, the rats were humanely killed. Eight rats from each group were randomly chosen for crater volume analysis by micro-computed tomography. For the remaining eight rats in each group, specimen slices were generated for histologic examination to determine the odontoclast number and the mean optical density value of RANKL.
The resorption volumes in the nicotine-treated group were significantly larger than those in the control groups. Also, the nicotine-treated group displayed significantly higher number of odontoclasts and elevated RANKL expression compared to the control groups.
In an in vivo rat model, nicotine exposure promotes odontoclastogenesis and RANKL expression, evoking aggravated root resorption during OTM.</description><identifier>ISSN: 0003-3219</identifier><identifier>EISSN: 1945-7103</identifier><identifier>DOI: 10.2319/101014-727.1</identifier><identifier>PMID: 26083055</identifier><language>eng</language><publisher>United States: Edward H. Angle Society of Orthodontists</publisher><subject>Animals ; Male ; Nicotine - adverse effects ; Nicotine - pharmacology ; Original ; Osteogenesis ; RANK Ligand - metabolism ; Rats ; Rats, Wistar ; Root Resorption - pathology ; Tooth Movement Techniques ; X-Ray Microtomography</subject><ispartof>The Angle orthodontist, 2016-03, Vol.86 (2), p.199-205</ispartof><rights>2016 by The EH Angle Education and Research Foundation, Inc. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-956652671397cfaff2badd34171c1f7f3aa8b9e443b5ffdece171f96d30115553</citedby><cites>FETCH-LOGICAL-c384t-956652671397cfaff2badd34171c1f7f3aa8b9e443b5ffdece171f96d30115553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603628/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8603628/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26083055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Wang, Xuxia</creatorcontrib><creatorcontrib>Li, Na</creatorcontrib><creatorcontrib>Zhenga, Dehua</creatorcontrib><creatorcontrib>Su, Yuran</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><title>Short-term effects of nicotine on orthodontically induced root resorption in rats</title><title>The Angle orthodontist</title><addtitle>Angle Orthod</addtitle><description>To investigate the effect of nicotine exposure on root resorption in an in vivo rat model of orthodontic tooth movement (OTM), and its association with odontoclastogenesis and receptor activator of nuclear factor-kappa B ligand (RANKL) expression.
Forty-eight 10-week-old male Wistar rats were divided into three groups. The negative control group was untreated. The left maxillary first molars in the nicotine-treated group and the positive control group received OTM with an initial force of 0.6 N in the mesial direction. Also, the nicotine-treated group received intraperitoneal injection of nicotine at 7 mg/kg per day. After 21 days, the rats were humanely killed. Eight rats from each group were randomly chosen for crater volume analysis by micro-computed tomography. For the remaining eight rats in each group, specimen slices were generated for histologic examination to determine the odontoclast number and the mean optical density value of RANKL.
The resorption volumes in the nicotine-treated group were significantly larger than those in the control groups. Also, the nicotine-treated group displayed significantly higher number of odontoclasts and elevated RANKL expression compared to the control groups.
In an in vivo rat model, nicotine exposure promotes odontoclastogenesis and RANKL expression, evoking aggravated root resorption during OTM.</description><subject>Animals</subject><subject>Male</subject><subject>Nicotine - adverse effects</subject><subject>Nicotine - pharmacology</subject><subject>Original</subject><subject>Osteogenesis</subject><subject>RANK Ligand - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Root Resorption - pathology</subject><subject>Tooth Movement Techniques</subject><subject>X-Ray Microtomography</subject><issn>0003-3219</issn><issn>1945-7103</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtKAzEUhoMotlZ3riUP4NScZDKXjSDFGxRE1HXI5GIj06QkqdC3d2S0KGdxFv93_gMfQudA5pRBewVkmLKoaT2HAzSFtuRFDYQdoikhhBWMQjtBJyl9EEI5L-kxmtCKNIxwPkXPL6sQc5FNXGNjrVE54WCxdypk5w0OHg_5Kujgs1Oy73fYeb1VRuMYQsbRpBA32Q2c8zjKnE7RkZV9Mmc_e4be7m5fFw_F8un-cXGzLBRryly0vKo4rWpgba2stJZ2UmtWQg0KbG2ZlE3XmrJkHbdWG2WGxLaVZgSAc85m6Hrs3Wy7tdHK-BxlLzbRrWXciSCd-J94txLv4VM0FWEVbYaCy7FAxZBSNHZ_C0R8qxWjWjGoFTDgF3__7eFfl-wLT652QQ</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Li, Jing</creator><creator>Wang, Xuxia</creator><creator>Li, Na</creator><creator>Zhenga, Dehua</creator><creator>Su, Yuran</creator><creator>Zhang, Jun</creator><general>Edward H. Angle Society of Orthodontists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Short-term effects of nicotine on orthodontically induced root resorption in rats</title><author>Li, Jing ; Wang, Xuxia ; Li, Na ; Zhenga, Dehua ; Su, Yuran ; Zhang, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-956652671397cfaff2badd34171c1f7f3aa8b9e443b5ffdece171f96d30115553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Male</topic><topic>Nicotine - adverse effects</topic><topic>Nicotine - pharmacology</topic><topic>Original</topic><topic>Osteogenesis</topic><topic>RANK Ligand - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Root Resorption - pathology</topic><topic>Tooth Movement Techniques</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Wang, Xuxia</creatorcontrib><creatorcontrib>Li, Na</creatorcontrib><creatorcontrib>Zhenga, Dehua</creatorcontrib><creatorcontrib>Su, Yuran</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Angle orthodontist</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jing</au><au>Wang, Xuxia</au><au>Li, Na</au><au>Zhenga, Dehua</au><au>Su, Yuran</au><au>Zhang, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term effects of nicotine on orthodontically induced root resorption in rats</atitle><jtitle>The Angle orthodontist</jtitle><addtitle>Angle Orthod</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>86</volume><issue>2</issue><spage>199</spage><epage>205</epage><pages>199-205</pages><issn>0003-3219</issn><eissn>1945-7103</eissn><abstract>To investigate the effect of nicotine exposure on root resorption in an in vivo rat model of orthodontic tooth movement (OTM), and its association with odontoclastogenesis and receptor activator of nuclear factor-kappa B ligand (RANKL) expression.
Forty-eight 10-week-old male Wistar rats were divided into three groups. The negative control group was untreated. The left maxillary first molars in the nicotine-treated group and the positive control group received OTM with an initial force of 0.6 N in the mesial direction. Also, the nicotine-treated group received intraperitoneal injection of nicotine at 7 mg/kg per day. After 21 days, the rats were humanely killed. Eight rats from each group were randomly chosen for crater volume analysis by micro-computed tomography. For the remaining eight rats in each group, specimen slices were generated for histologic examination to determine the odontoclast number and the mean optical density value of RANKL.
The resorption volumes in the nicotine-treated group were significantly larger than those in the control groups. Also, the nicotine-treated group displayed significantly higher number of odontoclasts and elevated RANKL expression compared to the control groups.
In an in vivo rat model, nicotine exposure promotes odontoclastogenesis and RANKL expression, evoking aggravated root resorption during OTM.</abstract><cop>United States</cop><pub>Edward H. Angle Society of Orthodontists</pub><pmid>26083055</pmid><doi>10.2319/101014-727.1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Male Nicotine - adverse effects Nicotine - pharmacology Original Osteogenesis RANK Ligand - metabolism Rats Rats, Wistar Root Resorption - pathology Tooth Movement Techniques X-Ray Microtomography |
| title | Short-term effects of nicotine on orthodontically induced root resorption in rats |
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