Lactobacillus rhamnosus GG Colonization in Early Life Ameliorates Inflammaging of Offspring by Activating SIRT1/AMPK/PGC-1α Pathway

Inflammaging refers to chronic, low-grade inflammation during aging, which contributes to the pathogenesis of age-related diseases. Studies have shown that probiotic intervention in the aging stage could delay aging-related disorders. However, whether the application of probiotics in early life coul...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.3328505-3328505
Hauptverfasser:	Liu, Tianyu, Song, Xueli, An, Yaping, Wu, Xuemei, Zhang, Wanru, Li, Jia, Sun, Yue, Jin, Ge, Liu, Xiang, Guo, Zixuan, Wang, Bangmao, Lei, Ping, Cao, Hailong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Animals, Newborn Antibodies Colon Feces Female Gastrointestinal Microbiome Gene Expression Regulation - drug effects Inflammation - microbiology Inflammation - pathology Inflammation - prevention & control Intestines - drug effects Intestines - microbiology Lactobacillus rhamnosus - physiology Male Mice Mice, Inbred C57BL Microbiota NF-kappa B - genetics NF-kappa B - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Pregnancy Probiotics - administration & dosage Proteins Sirtuin 1 - genetics Sirtuin 1 - metabolism Vagina
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