SAR study of 4-arylazo-3,5-diamino-1H-pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

By screening of a collection of 50 000 small-molecule compounds, we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of anti-biofilm agents. Here, we report a SAR study based on 60 analogues by examining ways in which the pharmacophore can be further optimized, for example, vi...

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Veröffentlicht in:	MedChemComm 2021-11, Vol.12 (11), p.1868-1878
Hauptverfasser:	Jansen, Charlotte U, Uhd, Jesper, Andersen, Jens B, Hultqvist, Louise D, Jakobsen, Tim H, Nilsson, Martin, Nielsen, Thomas E, Givskov, Michael, Tolker-Nielsen, Tim, Qvortrup, Katrine M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biofilms Chemistry Dispersal Pseudomonas aeruginosa Pyrazoles
Online-Zugang:	Volltext
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