Obesity is associated with reduced cerebral blood flow – modified by physical activity

•Increased BMI, WHR, and waist size associated with lower cerebral blood flow.•Waist size +1cm associated with same reduction in cerebral blood flow as +1year age.•Higher levels of physical activity shown to potentially modify these associations. This study examined the associations of body mass ind...

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Veröffentlicht in:	Neurobiology of aging 2021-09, Vol.105, p.35-47
Hauptverfasser:	Knight, Silvin P., Laird, Eamon, Williamson, Wilby, O’Connor, John, Newman, Louise, Carey, Daniel, De Looze, Celine, Fagan, Andrew J., Chappell, Michael A., Meaney, James F., Kenny, Rose Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging - physiology Alzheimer Disease - etiology Alzheimer Disease - prevention & control Arterial spin labeling MRI Body Mass Index Cerebral blood flow Cerebral perfusion Cerebrovascular Circulation Cross-Sectional Studies Dementia, Vascular - etiology Dementia, Vascular - prevention & control Exercise - physiology Female Gray Matter - blood supply Gray Matter - diagnostic imaging Humans Longitudinal Studies Magnetic Resonance Imaging - methods Male Middle Aged Obesity Obesity - complications Obesity - physiopathology Physical activity
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