Thermoresponsive polymeric dexamethasone prodrug for arthritis pain

Intra-articular (IA) glucocorticoids (GC) are commonly used for clinical management of both osteoarthritis and rheumatoid arthritis, but their efficacy is limited by the relatively short duration of action and associated side effects. To provide sustained efficacy and to improve the safety of GCs, w...

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Veröffentlicht in:	Journal of controlled release 2021-11, Vol.339, p.484-497
Hauptverfasser:	Zhao, Gang, Ren, Rongguo, Wei, Xin, Jia, Zhenshan, Chen, Ningrong, Sun, Yuanyuan, Zhao, Zhifeng, Lele, Subodh M., Zhong, Haizhen A., Goldring, Mary B., Goldring, Steven R., Wang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Arthritis, Experimental - drug therapy Arthritis, Rheumatoid Dexamethasone Glucocorticoid Hydrogel Pain Polymeric prodrug Prodrugs Thermoresponsive
Online-Zugang:	Volltext
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