Anticancer effects of mifepristone on human uveal melanoma cells

Background Uveal melanoma (UM), the most prevalent intraocular tumor in adults, is a highly metastatic and drug resistant lesion. Recent studies have demonstrated cytotoxic and anti-metastatic effects of the antiprogestin and antiglucocorticoid mifepristone (MF) in vitro and in clinical trials invol...

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Veröffentlicht in:	Cancer Cell International 2021-11, Vol.21 (1), p.1-607, Article 607
Hauptverfasser:	Alvarez, Prisca Bustamante, Laskaris, Alexander, Goyeneche, Alicia A., Chen, Yunxi, Telleria, Carlos M., Burnier, Julia V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Annexin V Breast Cancer Cancer therapies Cancer therapy Care and treatment Caspase-3 Cell cycle Cell death Cell growth Cell proliferation Chemotherapy Clinical trials Cytotoxicity Deoxyribonucleic acid Diagnosis DNA DNA fragmentation Drug repurposing Drug resistance Glucocorticoid receptors Glucocorticoids Lethality Liver Melanoma Meningioma Metastases Metastasis Mifepristone Mutation Ovarian cancer Patients Polymerase chain reaction Primary Research Progesterone Progesterone receptors Receptors Risk factors RNA-directed DNA polymerase Testing Tumors Uveal melanoma
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