Pyrrole Hemithioindigo Antimitotics with Near‐Quantitative Bidirectional Photoswitching that Photocontrol Cellular Microtubule Dynamics with Single‐Cell Precision

We report the first cellular application of the emerging near‐quantitative photoswitch pyrrole hemithioindigo, by rationally designing photopharmaceutical PHTub inhibitors of the cytoskeletal protein tubulin. PHTubs allow simultaneous visible‐light imaging and photoswitching in live cells, deliverin...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-10, Vol.60 (44), p.23695-23704
Hauptverfasser:	Sailer, Alexander, Meiring, Joyce C. M., Heise, Constanze, Pettersson, Linda N., Akhmanova, Anna, Thorn‐Seshold, Julia, Thorn‐Seshold, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic Agents - chemistry Antimitotic Agents - metabolism Biological control Cell Cycle Cell Death Cell Line, Tumor Cytoskeleton cytotoxicity HeLa Cells hemithioindigo Humans Indigo Carmine - analogs & derivatives Indigo Carmine - chemistry Indigo Carmine - metabolism microtubule dynamics Microtubules - chemistry Microtubules - metabolism Molecular Structure Photochemical Processes photopharmacology photoswitch Pyrroles - chemistry Pyrroles - metabolism Single-Cell Analysis Tubulin
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