Full‐Atom Model of the Agonist LPS‐Bound Toll‐like Receptor 4 Dimer in a Membrane Environment

The Toll‐like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD‐2) innate immunity system is a membrane receptor of paramount importance as therapeutic target. Its assembly, upon binding of Gram‐negative bacteria lipopolysaccharide (LPS), and also dependent on the membrane composition, finally...

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Veröffentlicht in:	Chemistry : a European journal 2021-11, Vol.27 (62), p.15406-15425
Hauptverfasser:	Matamoros‐Recio, Alejandra, Franco‐Gonzalez, Juan Felipe, Perez‐Regidor, Lucia, Billod, Jean‐Marc, Guzman‐Caldentey, Joan, Martin‐Santamaria, Sonsoles
Format:	Artikel
Sprache:	eng
Schlagworte:	Lipopolysaccharides Lymphocyte Antigen 96 - metabolism membrane proteins Molecular Docking Simulation molecular dynamics molecular modeling molecular recognition Signal Transduction Toll-Like Receptor 4 - metabolism Toll-like receptors
Online-Zugang:	Volltext
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