The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner

•Learning-induced Per1 cycles rhythmically in the RSC, peaking during the day.•Context fear conditioning transiently induces Per1 expression in the anterior RSC.•Per1 knockdown in the RSC during the day reduces context fear memory.•Daytime Per1 overexpression in RSC impairs context fear in a sex-spe...

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Veröffentlicht in:	Neurobiology of learning and memory 2021-11, Vol.185, p.107535-107535, Article 107535
Hauptverfasser:	Urban, Mark W., Lo, Chenyu, Bodinayake, Kasuni K., Brunswick, Chad A., Murakami, Shoko, Heimann, Ashley C., Kwapis, Janine L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circadian Clocks - genetics Circadian Clocks - physiology Circadian rhythm Conditioning, Classical - physiology Context fear conditioning CRISPR CRISPR-Associated Protein 9 CRISPR-Cas Systems Fear - physiology Female Gene Editing Gyrus Cinguli - metabolism Gyrus Cinguli - physiology Male Memory Consolidation - physiology Mice Mice, Inbred C57BL Per1 Period Circadian Proteins - physiology Retrosplenial cortex Sex differences Sex Factors
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